Senior Associate Scientist, Cargo Design And Delivery

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Associate Scientist, Cargo Design and Delivery, located in San Diego, CA.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

The Gene Therapy group of Janssen Therapeutics Discovery offers an exciting opportunity to help develop novel Gene Therapies for unmet medical needs. We are investigating the use of Adeno-Associated Virus (AAV) vectors for gene replacement and to deliver therapeutic proteins to patients for disease prevention as well as treatment. The successful candidate will add to our capabilities for assessing optimal cargo configurations and capsid profiles with a focus on evaluating expression and biological activity in relevant cells and tissues.

Key Responsibilities :

• Develop assays to evaluate AAV transduction in cell-lines, iPSC-derived cells, and primary tissues.
• Designing and implementing assays to analyze protein payloads for biochemical properties including binding and functional assays.
• Test engineered designs in cell culture and AAV vectors in animal models in collaboration with other Gene Therapy functional groups and therapeutic area scientists to measure gene expression levels, tissue specificity, and function to develop therapeutic leads.

Qualifications

Education:

• Minimum of a B.S./B.A. with at least 5 years of experience OR M.S. with at least 2 years of relevant experience in the pharmaceutical industry or academic environment is required.

Experience and Skills:

Required:

• Hands-on experience with mammalian tissue culture for a minimum of 2 years is required.
• Ability to design multicolor flow cytometry panels is required.
• Experience performing quantitative gene expression analyses such as ddPCR/ qPCR, reporter gene assays (such as luciferase, SEAP, and fluorescence), and/or immunohistochemistry is required.
• Ability to work collaboratively in cross-functional teams and across sites is required.

Preferred:

• Experience with iPSC and organoid models is preferred.
• Skillful at ex vivo tissue processing and analysis is preferred.
• Proficiency in bulk and single-cell RNA sequencing sample preparation is preferred.

The anticipated base pay range for this position $88,000 to $141,450.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company’s long-term incentive program.

Employees are eligible for the following time off benefits:

• Vacation – up to 120 hours per calendar year

• Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year

• Holiday pay, including Floating Holidays – up to 13 days per calendar year

• Work, Personal and Family Time - up to 40 hours per calendar year

Additional information can be found through the link below.

Certain types of paid time off are NOT available for Co-Ops, Interns and individuals represented by a Collective Bargaining Agreement (“CBA”)

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

This job posting is anticipated to close on March 2, 2024. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.