Address
Form of workTHE COMPANY
Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused R&D company with a portfolio of life-changing medicines. The company's Native Complex™ Platform recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular environment to enable new technologies for industrial-scale drug discovery for the entire GPCR target class for the first time. Septerna has an emerging pipeline of GPCR-targeted small molecule drug discovery programs, along with growth potential to reach many GPCRs that have been undruggable and unexploited to date. Septerna was launched by scientific founders who have made groundbreaking GPCR discoveries and by founding investor Third Rock Ventures. For more information see: www.septerna.com.
Join a multidisciplinary team of colleagues focused on creating revolutionary medicines to address significant needs of patients. Bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to our mission. At Septerna we embrace diversity of thought, expertise, and background; we share a fearless pursuit of ground-breaking innovations; and our employees learn from each other and succeed as a team.
THE ROLE
We are seeking a medicinal chemist with a track record of success to advance our chemistry efforts for one or more of our drug discovery programs. Reporting to the Senior Director, Medicinal Chemistry, this individual will be an integral member of the compound design team working cross-functionally with computational chemistry and DMPK. Responsibility for project chemistry (including managing outsourced chemistry relationships) from hit identification through the selection of drug candidates for clinical development is expected. In addition, the opportunity exists to contribute to establishing the company's internal chemistry capabilities, as well as ideas for new therapeutic programs. This will be an outstanding opportunity to collaborate with talented colleagues who all share a passion for developing new therapeutics that will make a difference for patients. The successful candidate will be motivated to discover new disease-modifying therapeutics for patients and enjoy working in a fast-paced dynamic team environment.
*Title commensurate with experience.
QUALIFICATIONS
This position requires a Ph.D. in organic chemistry with 7+ years of experience for Senior Staff Scientists and 9+ years of experience for Associate Directors in a biotechnology or pharmaceutical setting. The successful candidate will have experience contributing chemistry efforts for drug discovery programs. He/she will have deep expertise in organic/Medicinal Chemistry, experience with structure-based drug design, and experience optimizing compounds towards candidate selection.
REQUIREMENTS
•Extensive experience in Medicinal Chemistry, including optimization of physicochemical, ADME and safety-related properties relevant to orally bioavailable small molecule drug development, with a track record of patents and publications; experience with structure-based drug design is strongly preferred
•Contemporary expertise in all aspects of synthetic organic chemistry ranging from modern synthetic methodologies to techniques for synthetic route design, multi-step synthesis, compound purification and characterization
•Strong quantitative intuition including ability to analyze SAR data sets to drive lead optimization; proactively propose new strategies and new target molecules to improve key drug attributes
•A track record of successful management of external teams of chemists at contract research organizations is preferred
•Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
•A team player with strong collaboration, and organizational skills
•Experience with GPCR drug discovery and/or development of allosteric modulators is a plus
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused R&D company with a portfolio of life-changing medicines. The company's Native Complex™ Platform recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular environment to enable new technologies for industrial-scale drug discovery for the entire GPCR target class for the first time. Septerna has an emerging pipeline of GPCR-targeted small molecule drug discovery programs, along with growth potential to reach many GPCRs that have been undruggable and unexploited to date. Septerna was launched by scientific founders who have made groundbreaking GPCR discoveries and by founding investor Third Rock Ventures. For more information see: www.septerna.com.
Join a multidisciplinary team of colleagues focused on creating revolutionary medicines to address significant needs of patients. Bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to our mission. At Septerna we embrace diversity of thought, expertise, and background; we share a fearless pursuit of ground-breaking innovations; and our employees learn from each other and succeed as a team.
THE ROLE
We are seeking a medicinal chemist with a track record of success to advance our chemistry efforts for one or more of our drug discovery programs. Reporting to the Senior Director, Medicinal Chemistry, this individual will be an integral member of the compound design team working cross-functionally with computational chemistry and DMPK. Responsibility for project chemistry (including managing outsourced chemistry relationships) from hit identification through the selection of drug candidates for clinical development is expected. In addition, the opportunity exists to contribute to establishing the company's internal chemistry capabilities, as well as ideas for new therapeutic programs. This will be an outstanding opportunity to collaborate with talented colleagues who all share a passion for developing new therapeutics that will make a difference for patients. The successful candidate will be motivated to discover new disease-modifying therapeutics for patients and enjoy working in a fast-paced dynamic team environment.
*Title commensurate with experience.
QUALIFICATIONS
This position requires a Ph.D. in organic chemistry with 7+ years of experience for Senior Staff Scientists and 9+ years of experience for Associate Directors in a biotechnology or pharmaceutical setting. The successful candidate will have experience contributing chemistry efforts for drug discovery programs. He/she will have deep expertise in organic/Medicinal Chemistry, experience with structure-based drug design, and experience optimizing compounds towards candidate selection.
REQUIREMENTS
•Extensive experience in Medicinal Chemistry, including optimization of physicochemical, ADME and safety-related properties relevant to orally bioavailable small molecule drug development, with a track record of patents and publications; experience with structure-based drug design is strongly preferred
•Contemporary expertise in all aspects of synthetic organic chemistry ranging from modern synthetic methodologies to techniques for synthetic route design, multi-step synthesis, compound purification and characterization
•Strong quantitative intuition including ability to analyze SAR data sets to drive lead optimization; proactively propose new strategies and new target molecules to improve key drug attributes
•A track record of successful management of external teams of chemists at contract research organizations is preferred
•Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
•A team player with strong collaboration, and organizational skills
•Experience with GPCR drug discovery and/or development of allosteric modulators is a plus
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
