- Design, conduct and interpret in vitro experiments to profile ADME properties of drug candidates.
- Conduct and/or design hypothesis driven in vitro and in vivo studies to reveal the mechanism of drug disposition.
- Provide interpretation of in vitro, ex vivo and in vivo data that are generated both internally and with CROs; review and interpret bioanalytical data and reports; establish exposure-response relationships.
- Participate and contribute to project team meetings and presentations; represent DMPK as the subject matter expert and draft DMPK screening strategy.
- Manage and mentor scientists, including problem-solving for methods and instrumentation.
- Coauthor and review high quality regulatory documents and DMPK study reports.
- Participate in the preparation of abstracts, posters, and manuscripts for publication.
Education and Experience:
- PhD and PostDoc in Pharmacokinetics, Chemistry, Drug Metabolism, Pharmaceutical Sciences or other relevant field with 10+ years of industry experience.
- Strong scientific and technical knowledge in ADME profiling, drug metabolism, transport, SAR analysis and PK; hands on experience in operation and troubleshooting of HPLC and high-resolution mass spectrometers preferred.
- Experience in performing PK analysis using Phoenix or similar; experience with PBPK modeling a plus.
- Significant experience in PK/PD analysis, data interpretation and simulation.
- Proficiency in managing collaborations with CROs.
- Track record in mentoring and managing direct reports
- Effective in multidisciplinary project teams and enjoys interacting with colleagues across functions.
- Excellent oral and written communication skills.