Ngs Senior Research Associate/Senior Scientist, Antisense Lead Identification/Functional Genomics

Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the undisputed leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies.
As the first company to fully harness the power of RNA technology for human therapeutics, Ionis' platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals.
Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team. While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive. We believe engaging on a day-to-day basis, in person, builds solid and lasting relationships, and contributes positively to our culture and innovation. From the heart of our stunning Carlsbad campus, we aim to provide a central connection point for all our employees. These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow. Join us and experience our unique culture while you develop and expand your career.
NGS SENIOR RESEARCH ASSOCIATE / SENIOR SCIENTIST,
ANTISENSE LEAD IDENTIFICATION/ FUNCTIONAL GENOMICS
SUMMARY:
We are seeking an enthusiastic, highly motivated individual for the role of Senior Research Associate/Senior Scientist in our Lead Identification and Functional Genomics group. The successful candidate will join a fast-paced, highly productive, and innovative NGS Core team responsible for the expansion, refinement, and execution NGS analysis of in vitro and in vivo samples. The successful candidate is expected to be self-motivated and able to work productively in a matrixed environment. The role demands a strong biological sciences background, ideally in an automated high throughput setting. We offer a learning-rich R&D environment and encourage applications from highly motivated candidates.
RESPONSIBILITIES:

• Lead the refinement and execution of high throughput NGS sample preparation and sequencing for Antisense Research
  
  • RNA-seq and single cell analysis
• Design and perform routine and non-routine tests leading to the successful completion of developed experiments.
• Develop and perform novel NGS assays, including new methods for sample preparation, library build, or sequencing.
• Oversee NGS studies including submission, tracking, execution, and analysis, maintaining effective communication with requesters.
• Collaborate with multiple group leaders to refine objectives and prioritize development and experiments.
• Carefully interrogate the existing protocols. Design and execute molecular biology and automation experiments to improve efficiency.
• Independently analyze complex/large data sets and troubleshoot results.
• Operate and troubleshoot liquid handler automation and robotics for assay development.
• Independently design, execute, and analyze in vitro experiments.
• Provide guidance, leadership, and supervision to the team.

REQUIREMENTS:

• Full-time, on-site position
• B.S./M.S./Ph.D. degree in molecular biology, biology, biochemistry, or related field.
• Minimum of 5 years' experience working in an academic or industrial laboratory setting.
• Proven ability to independently execute experiments, analyze results, and design follow-up experiments.
• Intuitive problem-solving skills, with an ability to identify deviations and troubleshoot independently.
• Proficiency in advanced genomics approaches (NGS pipelines, single-cell methodologies) and cell/molecular biology techniques (nucleic acid extraction, cell and nuclear dissociation, RT-qPCR).
• Strong understanding or interest in genomics and transcriptomics, including gene expression and modulation.
• Familiarity with NCBI, UCSC genome browser, and other public databases.
• Enthusiasm for high throughput automation and its application in enhancing efficiency.
• Experience in managing large sample sets and data tracking (Excel and structured datasets), with a keen attention to detail.
• Excellent organizational, time management, and project prioritization skills, adaptable to an intense work environment.
• Desired experience in leadership and team supervision.

Please visit our website, www.ionispharma.com for more information about Ionis and to apply for this position; reference requisition #IONIS003172
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded
The pay scale for this position is $90,000 to $144,650
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.