Scientist I/Ii, Investigative Toxicology

pDescription:/pulliThis position is in the Investigative Toxicology Group within the department of Safety Assessment in Genentechrsquo;s Research and Early Development organization./liliThe mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed non-clinically and/or in clinical trials through hypothesis driven research./liliThis process involves closely collaborating with scientists across the organization to support the overall safety assessment for our novel therapeutics spanning drug discovery through clinical development and marketing./liliThe group provides fit-for-purpose wet lab-based investigation to address target safety assessment, lead optimization, and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches./liliAs such, we are constantly establishing new platforms and technologies to support a constantly changing portfolio, novel modalities, and emerging therapeutic area needs./liliWe are looking for a highly motivated candidate to work in collaboration with other researchers in the Investigative Toxicology lab./liliThis individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies./liliThis individual will be working with cells from a broad range of tissues (immune cells, blood, liver, vascular, ocular, immortalized cell lines) and is expected to make detailed observations related to experiments, perform, analyze data, and interpret results./liliThis individual will contribute scientific insights and work in projects related to peer review publications./li/ulpbr /Job Description/pulliGenentech has an open Scientist I/II position in the Investigative Toxicology group within the department of Safety Assessment located in our South San Francisco campus./liliThe Investigative Toxicology grouprsquo;s goal is to use ex vivo and in vitro tools to assess safety liabilities and mechanisms of toxicities observed pre-clinically to support the entire portfolio spanning discovery through development./liliThis laboratory-based role involves performing, qualifying, and implementing biological assays and technologies to support the Investigative Toxicology group./liliThis is an ideal position for a researcher who is enthusiastic about learning and contributing to projects with a broad range of techniques./liliAs such the position requires excellent communication and collaboration skills, a desire to learn about and integrate multiple aspects of drug toxicity, and a passion for lab-based research./li/ulpbr /br /Skills:/pulliCandidate will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by:ulliPerforming experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. Experience with these methodologies is desirable, but not required./liliMaintaining documentation related to protocol execution and results./liliWriting protocols and contributing to final reports as appropriate./liliAdhering to departmental SOPs to ensure study integrity and quality./liliConducting experiments with a high level of independence and initiative./liliPerforming tasks with minimal direct supervision for routine methods and studies commonly employed by the team./li/ul/li/ulpbr /Education:/pulliBachelors (BS/BA) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline is required;/liliMasters (MS) degree is desirable, but not required./li/ulpbr /Technical Experience Requirements:/pulli1-3+ years of laboratory experience with hypothesis-driven research.nbsp;/liliAbility to analyze, integrate, and present data in a presentation is required./liliExperience with immortalized and/or primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry is highly desired./liliExperience with complex in-vitro model systems is highly desired./li/ulpbr /Role will Involve:/pulliSitting or standing for extended periods./liliPerforming repetitive tasks such as cell culture, pipetting and labeling tubes./liliCollaboration across the Investigative Toxicology team and with key stakeholders./liliWork with potentially hazardous materials including (but not limited to): chemotherapeutics, biological hazards, and human primary cells./li/ulpThis is the pay range that Magnit reasonably expects to pay for this position: $30.96/hour-$55.57/hour/ppBenefits: Medical, Dental, Vision, 401K (provided minimum eligibility hours are met)/ppMagnit has an ongoing commitment to the diversity and inclusion of all team members. We believe that embracing diversity leads to innovation and helps address the needs of the business. We welcome individuals from different backgrounds, experiences, and cultures to join our team. We value this diversity and strive to create an inclusive environment that celebrates these unique perspectives, allowing you to contribute to your full potential. Finally, but most importantly, we expect all team members to be treated with dignity and respect./ppIf you have a disability and need an accommodation in relation to the online application process, please email us at Roche.Accommodations@magnitglobal.com/p