Senior Associate Scientist, Non-Viral Gene Therapy

Job Title:Senior Associate Scientist, Non-Viral Gene Therapy
Grade/Level: L1-2
Hiring Manager: Hong Wang
Location: GMU, 225 Second Ave, Waltham, MA 02451
Job Type: Permanent
Our Team:
The Non-Viral Gene Therapy (NVGT) group within the Genomic Medicine Unit (GMU) of Sanofi creates innovative drug delivery modalities for treating genetic disease. The NVGT group specifically is responsible for designing, formulating, analyzing, and assessing efficacy of lipid nanoparticle (LNP) based therapeutics.
Job Description:
Sanofi is seeking a highly motivated Senior Associate Scientist to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in the formulation of lipid nanoparticles, with significant understanding of nanoparticle characterization methods and instruments, as well as protein engineering workflows.
Responsibilities:

• Execute lipid nanoparticle formulation and characterization.
• Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues.
• Perform downstream analytical assays such as SDS-PAGE, ELISA, SEC, RP-HPLC, DSF, SPR, or BLI.
• Perform incorporation of targeting antibody into LNPs and execute associated analytical assays.
• Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members.
• Plan, execute, and record experiments as guided in a time sensitive manner.
• Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory.
• Author standard operating procedures, study plans and reports and present findings.
• Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture.

Requirements:

• BS in Chemistry, Chemical Engineering, Biological Engineering, or a related field with a minimum of 3 years of relevant industry experience.
• Direct experience with small- and large-scale production of lipid nanoparticles for research use, ideally for both hepatic and extrahepatic delivery.
• Direct purification experience with TFF and AKTA chromatography.
• Experience with mRNA/DNA and LNP analytical characterization such as particle size, zeta potential, gel electrophoresis, UV-vis spectroscopy, RP-HPLC etc.
• Familiarity with protein and antibody engineering workflows, ideally expression, purification, characterization.
• Preferred to have familiarity with bioconjugate and biorthogonal chemistry.
• Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting.
• Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn.
• Demonstrated ability to independently design, execute, interpret, and present experimental results.
• Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.