Senior Research Scientist - Dpmk

Ready to make a difference in the lives of patients all around the world? As a leading clinical-stage biopharmaceutical company, that’s our top priority. 

Established in 2018, Aligos became a publicly-traded company in 2020. Our employees thrive in a science-first culture with many critical domains represented on staff. Our team of respected scientists use their decades of experience to build cutting-edge pipelines of transformative treatment options that change lives. We do this by utilizing our proprietary oligonucleotide and small molecule platforms to develop novel therapeutics that address critical unmet needs in liver and viral diseases—such as NASH, COVID-19 and Chronic Hepatitis B. With three compounds already in the clinic and a diverse portfolio of assets in a variety of indications, we are poised for growth and excited for what comes next.

At Aligos, you’ll have an opportunity to pursue your passion among the best in the industry. It’s a place where you’ll be challenged, supported, and inspired. A highly-collaborative, fast-paced work environment where we honor accountability, transparency, and diversity.   

Position Summary/About the Team:
This position will report to Senior Director DMPK and be responsible for providing DMPK expertise for new chemical entities, small molecule and oligonucleotides, as a project representative on multi-disciplinary drug discovery and development teams.  The position will have high visibility within the company and is expected to contribute directly to the company’s goals and objectives. 

Essential Functions / Responsibilities:

• Work closely with nonclinical discovery scientist, clinicians and cross-functional project team members. Participate as functional representative on discovery/development project teams. 
• Provide leadership and guide discovery project teams for candidate selection, develop and drive DMPK strategies for lead optimization and solving ADME-related issue. Design, conduct and interpret in vitro and in vivo DMPK studies. 
• Determine PK parameters for nonclinical studies using WinNonlin and assist with the application of modeling approaches (in silico, PK, PBPK) to support human pharmacokinetics and dose predictions, quantitative risk assessment of drug-drug interactions. 
• Generate, analyze and present data, both orally and as written reports. 
• Author and review various regulatory documents that are required for worldwide regulatory submissions.     

Reasonable accommodations may be made to enable individuals with disabilities to perform these essential functions.

Required Education and Experience:

• PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule and oligonucleotide pharmacokinetics and metabolism with 5+ years of relevant industry experience. 
• Extensive understanding of DMPK principles. A proven track record of supporting drug discovery and development as a functional representative on multidisciplinary project teams, authoring reports, regulatory documents, supporting worldwide regulatory filings and interactions. 
• Proven skills in pharmacokinetic data analysis using Phoenix WinNonlin.  
• Knowledge of GLP, GCP, drug development and regulatory guidelines is required. 

Preferred Education and Experience:

• Familiarity with NONMEM, SimCyp and/or Gastroplus PBPK modeling is nice to have.

Additional Eligibility Qualifications/Competencies

• Ability to adapt quickly, succeed in a team environment and learn new tasks independently.
• Excellent interpersonal and communications skills, ability to build productive internal/external working relationships with cross-functional teams. 

• The successful candidate must be flexible and adaptable to the needs of a small company.
• The ability to multitask and prioritize to delivery results within tight timelines is a must.

Work Authorization/Security Clearance

All candidates are expected to have authorization to work in the United States.

Supervisory Responsibility

Manage and guide CRO’s 

Position Type and Expected Hours of Work

This is a full-time position. Expected days and hours of work are Monday through Friday, 40 hours per week.

Physical Requirements 

It is expected that the employee is able to sit / stand at a desk and have full use of a computer through its standard input devices (e.g., mouse and keyboard).

Travel

This position is located in South San Francisco, CA and may require approximately 10% travel.

Other Duties:

As the company grows, this position is expected to have direct reports and interns.  Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for their job. Duties, responsibilities and activities may change at any time with or without notice.

Work Environment

This position works in a standard office setting, in a facility that contains laboratory equipment.

EEO Statement:

Aligos Therapeutics, Inc. is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to sstakes@aligos.com. 

Benefits and Compensation 

Aligos Therapeutics provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), Critical Illness, Accident, Legal and ID Theft, 401k plan, PTO, and ESPP (Employee Stock Purchase Plan).

The anticipated salary range for fully qualified candidates applying for this role will be $133,000– $194,000 (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.