Scientist Ii (Molecular Biology)

Summary:

The prospective Scientist II will pioneer the efforts to characterize sa-mRNA sequence-structure-function relationship at key steps during the sa-mRNA product development process, using RNA structural and functional analyses powered by next-generation sequencing (NGS) technologies. The successful candidate is expected to play a significant role in cross functional collaborations with data sciences, discovery research and analytical teams. You will provide scientific expertise for sa-mRNA platform and program development projects and mentor junior scientists.

Responsibilities:

• Develop novel NGS (Illumina and Nanopore) library preparation workflows for characterization of sa-mRNA structural features and stability profiles in a variety of contexts.
• Provide molecular understanding of sa-mRNA IVT, purification and encapsulation process.
• Derive insights from NGS-based studies for sa-mRNA technology and process improvement.
• Work with data science team to develop predictive modeling approaches for sa-mRNA sequence and structure optimization.
• Assist development of high throughout arrayed and pooled sa-mRNA library screening
• Work with automated liquid handlers for high throughput NGS library preparation
• Author study protocols, development and characterization reports, as well as scientific

manuscripts for external publication

• Ensure all experimental procedures and documentation are compliant with highest quality

and regulatory standards

• Present results and findings at internal and external meetings
• Provide guidance to junior team members, interns, and act as a resource for colleagues with

less experience

• Strong expertise in RNA biochemistry and RNA biology
• Extensive experience in NGS library preparation, sequencing, and bioinformatic analysis
• Experience with culturing mammalian cell lines and primary cells
• Experience with mRNA structural probing and/or stability profiling
• Drug discovery experience in the field of RNA therapeutics is a strong plus
• Familiarity with synthetic biology tools and applications is highly desirable
• Peer-reviewed publications that can showcase your skills
• Values ethics, integrity and trust, perseverance and problem solving
• Effective verbal & written communication skills in a cross functional environment

Our Benefits

CSL Seqirus employees that work at least 30 hours per week are eligible for benefits effective day 1. We are committed to the wellbeing of our employees and their loved ones. CSL Seqirus offers resources and benefits, from health care to financial protection, so you can focus on doing work that matters. Our benefits are designed to support the needs of our employees at every stage of their life. Whether you are considering starting a family, need help paying for emergency back up care or summer camp, looking for mental health resources, planning for your financial future, or supporting your favorite charity with a matching contribution, CSL Seqirus has many benefits to help achieve your goals.

Please take the time to review our benefits site to see what’s available to you as a CSL Seqirus employee.

About CSL Seqirus

CSL Seqirus is part of CSL Limited (ASX: CSL). As one of the largest influenza vaccine providers in the world, CSL Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. Learn more about CSL Seqirus.

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