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Form of work
SalaryPOSITION SUMMARY:
We are looking for a highly motivated Scientist or Senior Scientist to develop and apply state-of-the-art chemoproteomics technologies to address compelling questions in biology, chemistry and translational medicine. You will join a team responsible for drug discovery and biomarker discovery/validation in neurodegenerative diseases and cancer.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Design and implement chemoproteomic experiments for the assessment of the mechanism of action and selectivity of specific compounds under investigation.
- Working with medicinal chemists, develop and optimize novel, fit-for-purpose chemical biology tools and techniques.
- Implement orthogonal chemoproteomics workflows, including affinity pulldown, photoaffinity labeling, thermal proteome profiling, and covalent screening.
- Mentor research associates and collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis.
- Other duties as assigned.
REQUIREMENTS:
- Requires a Ph.D. degree in Biology, Biochemistry, Chemistry or Analytical Sciences; relevant Postdoctoral experience preferred.
- Scientist: 0-3 years industry experience; Senior Scientist: 4+ years industry experience.
- 3+ years' experience working with nanoLC-MS/MS instrumentation and data.
- A strong background in investigating biology with chemical tools.
- Ability to apply and/or develop affinity and activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess the selectivity of compounds.
- Strong familiarity with molecular glues or bifunctional degraders preferred.
- Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues.
- Demonstrated ability to analyze, interpret, and present data in a clear fashion.
- Solid scientific training/productivity as identified through high-impact publications demonstrating creative thinking as well as innovative technical approaches.
