Research Associate Ii - Senior Research Associate In Vivo

WHAT WE DO:

Calidi Biotherapeutics is a clinical-stage immuno-oncology company with proprietary technology that is revolutionizing the utilization of oncolytic viruses through an allogeneic cell-based delivery system. Calidi Biotherapeutics is advancing this potent stem cell and oncolytic virus combination for use in multiple difficult-to-treat oncology indications. Our team is also developing a universal cell delivery system to protect, amplify and potentiate oncolytic viruses currently in development.

GENERAL PURPOSE OF JOB:

Performs research and/or development in collaboration with others for projects. Makes

detailed observations, analyzes data and interprets results. Research involves the use of oncolytic viruses, tumor biopsies, murine and human cells cell lines, experimental cancer model tissues, and blood from cancer patients and healthy donors.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Performs high level tasks and play a lead role in animal studies including planning, dosing, executing IN VIVO experiments under limited supervision.
• Examines data and prepare technical reports, summaries, protocols, and quantitative analysis, ensuring experiments are well documented and comply with regulatory requirements.
• Presents data to internal project teams.
• Fields questions from Research Associates and escalate to scientific leadership as necessary. Assist in troubleshooting.
• Performs IN VIVO studies to evaluate efficacy in murine models.
• Administrates of test substances by various routes (i.e., intratumoral, IP, IV, SC, PO, topical, etc.).
• Performs mouse necropsies, tissue harvest, and mouse blood collection via: cardiac puncture, submandibular, retro orbital etc.).
• Performs IN VIVO imaging to monitor tumor growth (IVIS or equivalent).
• Maintains and Update IACUC.
• Leads coordination with other team members vivarium activities for supplies, audit, organizes.
• Trains new RAs in vivarium on documentation and techniques.
• Works with the study director to develop Protocols, study plans and timelines and coordination of activities.
• Coordinates and keep track all animal studies in house (status, summary overview).
• Supports in vitro assays: cell cultures, qPCR, histology, xcelligence.
• Manages and observes animals for general health and overall well-being.
• Adheres to SOPs to ensure study integrity and quality.
• Maintains accurate experiment records in various internal databases and perform basic data analysis.
• Adheres to good health and safety practices and compliance with applicable EH&S rules and participating in mandatory safety training programs.
• Independently performs all methods and conduct all study types commonly employed by the team.
• Performs other duties as directed by Management

EDUCATION and/or EXPERIENCE:

• B.S. or higher in life science, or related field
• 5 or more years of experience animal laboratory setting
• Current knowledge of pre-clinical tumor models, animal handling and dosing.
• Strong hands-on experience with animal handling, dosing (Intratumoral, IP, IV, PO, and SC), bleeding, necropsy and tissue harvest.
• Experience in immuno-oncology, TILS isolation, and flow cytometry is a plus.
• Experience in in vitro assay; like qPCR, cloning, ELISA will be preferred.
• Good organizational and documentation skills.
• Dedication to working in a team-oriented environment to contribute to shared project.
• Strong work ethic, self-motivation, and ability to multi-task in a fast-paced work environment.
• Strong knowledge of MS Word, Outlook, PowerPoint, Excel.

MATHEMATICAL SKILLS:

• Ability to work with mathematical concepts such as calculation of dilutions and statistical analyses.
• Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations.

REASONING ABILITY:

• Ability to define problems, collect data, establish facts, and draw valid conclusions.

LANGUAGE SKILLS:

• Excellent communication skills with ability to effectively communicate with other research teams

• Ability to read and understand technical procedures.
• Ability to write protocols and reports.
• Ability to effectively present data and respond to questions from co-workers.

CERTIFICATES, LICENSES, REGISTRATIONS:

• None required.

The PERKS:

• Weekly onsite meals, daily snacks and beverages
• Team building activities
• Competitive Total Rewards package (Medical, Dental, Vision, 4% 401k Safe Harbor Match) offered to full-time employees

WORK LOCATION:

Calidi Biotherapeutics employment provides the opportunity to work in beautiful San Diego, California only minutes from the nearest beach.

EOE and Accommodation:

We value diversity and are proud to be an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law. Calidi Biotherapeutics provides reasonable accommodation in job application procedures for qualified individuals with disabilities and disabled veterans. If you need accommodation in connection with the recruiting process due to a disability, you may include this information in your cover letter. If you are selected to interview for a position, you may also request an accommodation with our team directly.

Notice to Agency and Search Firm Representatives

Calidi Biotherapeutics is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Calidi Biotherapeutics employee by a third-party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Calidi Biotherapeutics. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral.

EMPLOYER’S RIGHTS:

This job description does not list all the duties of the job. You may be asked by supervisors or managers to perform other duties. You will be evaluated in part based upon your performance of the tasks listed in this job description.

The employer has the right to revise this job description at any time. The job description is not a contract for employment, and either you or the employer may terminate employment at any time, for any reason.