Associate Director/Senior Research Investigator/Research Investigator, Pbpk

Working with UsChallenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.The scientist in this role will join an established Physiologically Based Pharmacokinetic (PBPK) modeling team with demonstrated and growing impact across the pipeline.  PBPK modeling has become an important component of drug discovery and development.  PBPK models are used to characterize the drug absorption, distribution, metabolism, and excretion (ADME) properties based on calibration to non-clinical and clinical data.  This enables extrapolation and generation of hypotheses to inform clinical development.  Additional applications include drug-drug interaction (DDI) risk assessment, PK and dose predictions in humans and special populations, prediction of target tissue concentrations, formulation optimization, and early differentiation between lead and backup molecules.  PBPK models are often extended to provide projections of target engagement, and pharmacodynamics have been incorporated.  Our QSP&PBPK team has established expertise, impact, tools, a strong intellectual environment, and capable colleagues.  The individual in this role will take on a variety of projects across therapeutics areas as well as preclinical and clinical development.  An individual is being sought at the associate director level, but talented colleagues at other levels may be considered and the level offered would be commensurate with relevant experience.Responsibilities:Provide leadership to and collaboration with multidisciplinary project teams to develop and apply PBPK modelsDemonstrate high proficiency in the development and application of PBPK models to address drug discovery and development questionsPartner with external groups to accelerate the internal PBPK efforts in key disease areasIndependently provide expert support to project teams to design, execute and interpret clinical pharmacology studiesCoordinate with QSP&PBPK methods group on new methodologies for innovative PBPK model development and applicationNetwork with stakeholders in non-clinical DMPK, biotransformation, and pharmaceutical development to identify and interpret experiments critical for model development and refinementAlign PBPK model deliverables with clinical pharmacology, pre-clinical, and clinical development plans as appropriateBegin to learn how to align application area PBPK strategy with organizational prioritiesContribute to the standards of practice within the departmentParticipate and contribute to departmental and research initiativesServe as a subject matter expert to both internal colleagues and the external scientific DMPK/CPPDB communityStay informed with emerging literature and science in the DMPK and PBPK fieldsEstablish and maintain effective collaborations with stakeholders in other functional areasBuild and maintain a personal track record of publication in the area of PBPKMaintain an active relationship with colleagues in Clinical Pharmacology, Pharmacometrics, Disposition & Bioanalysis at the project level as well as in the advancement of PharmacometricsPosition requirements:Ph.D. in pharmaceutics, clinical pharmacology, engineering, toxicology or a related fieldFor the Associate Director role, 5+ years of post-PhD pharmaceutical industry experience in applying PBPK modelingFor Sr. Research Investigator level, in addition to the Ph.D., 2+ years of post-PhD pharmaceutical industry experience in applying PBPK modelingFor. Research Investigator level, in addition to the Ph.D., 0-2 years of post-PhD pharmaceutical industry experience in applying PBPK modelingExperience within pharmaceutical industry or pharmaceutical consulting is desired (academic post-doctoral or faculty may be a consideration depending on the totality of prior experience)Candidates with less education and industry experience may be considered for a lower starting grade, commensurate with education and experienceM.S. in appropriate field with significantly more experience may be consideredExcellent understanding of the theory and principles in pharmacokinetics and pharmacodynamics, drug metabolism and transportersUnderstanding of the theory, principles and statistical aspects of mathematical modeling and simulationAbility to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop PBPK modelsAbility to communicate internally and externally on topics related to Clinical Pharmacology and PBPK is requiredAbility to keep up to date with and propose the implementation of scientific and technological developments in the area of PBPKExperience with general programming and data analysis tools/languages such as MATLAB, R, Spotfire, etc, is desirableExperience developing bespoke models in SimBiology is a plusDesire to interact as a modeling and simulation expert with matrix project teams working closely with experts from different functional areas (pre-clinical and clinical)Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as clinical pharmacologyDemonstrated leadership and publication in PBPKFor position offered in California, the starting compensation for Senior Research Investigator job is a range from [$140,000-$170,00).  For Research Investigator job is a range from ($126,000-$155,000). And for Associate Director job is a range from ($159,000-$220,000), plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.#LI-HYBRIDIf you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as “Transforming patients’ lives through science ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.