Postdoctoral Fellow - Lead Discovery & Characterization

Career Category
Postdoctoral
Job Description
HOW MIGHT YOU DEFY IMAGINATION?
You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.
Postdoctoral Fellow - Lead Discovery & Characterization
Live
What you will do
Let's do this. Let's change the world. In this vital role you will gain access to Amgen's ground breaking technologies and innovation and are expected to make scientific contributions to the field. This includes presenting at scientific conferences and publishing their work. Postdocs will be part of the broader R&D Postdoc Program, focusing on training the next generation of industry scientists. An overwhelming majority of our postdocs advance their careers in the industry at leading pharma and biotech companies, including many at Amgen.
The research direction will be in the area of Targeted Protein Degradation, with a specific focus on molecular glues. The postdoc will apply NMR spectroscopy to create novel methodologies for the discovery and development of molecular glue molecules, taking a multi-disciplinary approach that combines computational methods and experimental techniques.
The successful candidate will:

• Express and purify stable-isotope labeled proteins in quantities required for NMR structural studies,
• contribute to the design and execution of fragment screening campaigns to support hit identification, validation, compound progression and mechanism of action studies,
• design, implement and complete NMR experiments to enable structural studies on protein-protein interactions modulated by small molecules,
• use NMR data as input into software packages for the purposes of 3-D structure determination/improved prediction.

The approach will involve, but is not limited to, comprehensive structural assessment of targets, including protein dynamics, fragment-based Lead Discovery, and characterization of target-ligase complexes. Successful applicants will hold a Ph.D. in Chemistry, Physics, Biophysics, or a related field, and have a firm knowledge of NMR spectroscopy, as well as wet-lab experience. Previous experience in molecular modeling and simulation is an advantage.
Amgen's biophysical NMR facilities are equipped with Bruker 500, 600, and 800 MHz instruments with cryoprobes and SampleJet's. Other Biohysical methods that can be employed include SPR, ITC, DSF and MS capabilities. This role is a great opportunity to join the fast-growing field of Induced Protein Proximity applied to drug discovery. The position provides opportunities to to develop novel approaches and collaborate effectively in cross-functional project team settings with other biophysicists, structural biologists, chemists, and biologists.
The postdoctoral position is intended for a 3 year term, with the option of an additional year.
Win
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The Postdoctoral Fellow we seek is a collaborator with these qualifications.
Basic Qualifications:
PhD at time of appointment
Preferred Qualifications:

• PhD in biochemistry, molecular biology, chemistry, physics.
• Good understanding of biomolecular NMR in solution. Practical experience working with NMR instrumentation.
• Strong interest in combining computational drug design approaches with experimental data. Experience with docking software.
• Python/Matlab practical knowledge. Previous experience with Rdkit is beneficial, but not strictly required.
• Experience with protein isotope-labeling will be a plus.
• Excellent organizational, interpersonal and communication skills
• A passion to explore the unknown and make discoveries that will chart new areas of biology

Thrive
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Salary Range
76,773.00 USD - 87,171.00 USD