Senior Scientist / Principal Scientist, Functional Genomics

Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland.  For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology.  Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the undisputed leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies.

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis’ platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.  We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence.  Our success is a direct result of our outstanding employees.  We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team.  While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive.  We believe engaging on a day-to-day basis, in person,  builds solid and lasting relationships, and contributes positively to our culture and innovation.  From the heart of our stunning Carlsbad campus,  we aim to provide a central connection point for all our employees.  These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow.   Join us and experience our unique culture while you develop and expand your career.

SENIOR SCIENTIST / PRINCIPAL SCIENTIST, FUNCTIONAL GENOMICS

Join a dynamic team within the Functional Genomics group. We are passionate about unraveling the mysteries of genome instability in aging and age-related diseases. In this role, you'll help lead pioneering research to understand the role of genome instability and genetic variation in neurodegenerative diseases. You will also utilize your expertise in NGS data analysis to analyze large and complex datasets generated by our wet-lab team. Broader collaboration across the company is key, as you'll work closely with other interdisciplinary teams composed of biologists, computational biologists, chemists, and others. Embrace this opportunity to thrive in a dynamic and results-driven environment and contribute to the discovery of next-generation molecular targets and therapies. 

KEY RESPONSIBILITIES: 

• Investigate genome instability in preclinical models of aging and disease, focusing on microsatellite expansion, transposable elements, and repetitive sequences
• Integrate and analyze NGS datasets encompassing genome structure data, DNA sequencing, transcriptomics, and DNA methylation
• Develop and document analysis methodologies
• Collaborate with cross-disciplinary teams and present findings to a diverse audience including biologists, chemists, and statisticians
• Perform additional duties as required

REQUIREMENTS: 

• PhD in Genomics, Computational Biology, Biostatistics, Biological Sciences, Mathematics, or Engineering
• 3+ years of post-graduate experience in relevant fields
• Proficiency in the best practices of Next-Gen Sequencing data analysis, covering techniques like single-cell RNA-seq, multiome analysis, bulk RNA-seq, ChIP-seq, ATAC-seq, CRISPR on/off-target analysis, mobile element mapping, and somatic mutation calling
• Strong familiarity with Linux, cloud computing, and scripting languages such as Python and R 
• Expertise in statistical genetics, genetic epidemiology, and CRISPR-Cas9 genome editing
• A robust record of innovative research, as evidenced by publications and presentations 
• Exceptional oral and written communication abilities
• Capability to thrive in a fast-paced work environment. 
  

Please visit our website, www.ionispharma.com for more information about Ionis and to apply for this position; reference requisition # IONIS003237

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded

The pay scale for this position is $98,794 to $160,000

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.