Address
SalaryVilya is a computational biotechnology company creating a novel class of medicines to precisely target disease biology. We believe computational approaches are an integral, if not foundational, component of drug discovery and development. Our platform is built on ground-breaking research in advanced computational approaches and taps into uncharted chemical space to design new molecular structures not found in nature.
We are harnessing the power of our platform to go after previously impossible targets in an array of indications. Vilya’s ultimate goal is to solve some of the most challenging unmet medical needs that exist today.
Our Vision: Harness a revolution in technology and biology to better human health
Our Mission: Build an independent, leading biotech company founded on intelligent drug design to cure the incurable
We are seeking a versatile, self-motivated DMPK Senior Scientist to become an integral part in the discovery of macrocycle drug candidates. Our early-stage pharmaceutical company strives to employ the latest advances in technology to progress our ambitious drug discovery projects. A collaborative teammate seeking scientific rigor in a disruptive biotech would be well suited for this role.
RESPONSIBILITIES:
- Incorporate robotics and other automated processes to increase data output.
- Establish in vitro ADME assays (metabolic, stability, drug permeability, and protein binding) to support multiple discovery programs.
- Manage CRO's in the conduct of in vivo DMPK studies.
- Work with internal teams and CRO's to coordinate assays for drug discovery projects.
- Facilitate the establishment of a DMPK laboratory in a new build.
- Establish and maintain transparent experimental records via electronic notebooks and integrated databases.
- Analyze, interpret, summarize, and present PK and ADME data to internal project teams.
- Work closely with project teams, line management, and CRO's to assure high quality and timely delivery of written reports for regulatory submissions.
PREFERRED QUALIFICATIONS:
- Ph.D. (or equivalent industry experience) in analytical chemistry, pharmacokinetics, pharmacology, biochemistry, with 2+ years of experience, or relevant technical field experience
- Extensive background and skills in LC-MS-MS analysis using triple quadrupole and QToF instruments.
- Experience with high-throughput DMPK workflows- automation, programming, and equipment maintenance.
- Good knowledge of DMPK experimental aspects, including high resolution mass spectrometry, bioanalytical analysis, microsomal stability, metabolite identification, CYP inhibition and induction, plasma protein binding, and solubility determinations.
- DMPK drug discovery experience, ideally with both large and small molecules.
- Expertise in drug metabolism and pharmacokinetic/dynamic principles.
- Excellent people skills and an ability & willingness to work on a multidisciplinary R&D team.
VILYA BENEFITS:
- Opportunity to work in a disruptive startup with a talented, experienced, and growing team of dedicated individuals
- 401(k) plan with employer matching for contributions
- Stock options
- Excellent medical, dental, and vision coverage
- Open, flexible vacation policy
- Support to attend professional conferences that are meaningful to your career growth
- Monthly cell phone stipend
- Commuter benefits
- Salary Range : $130,000 - $160,000
