Address
Form of workJob Description
We are seeking a highly motivated Senior Scientist to join our Biologics Potency team within the Cell Based Sciences, Analytical Research and Development organization of our company's Research Laboratories at Kenilworth, NJ. The qualified candidate will be responsible for developing, establishing pre-qualification and robustness, and transferring immunoassays and cell-based potency assays to assess the biological activity of various biologics modalities such as antibodies, multifunctional proteins, peptide therapeutics, antibody-drug-conjugates, and novel biologics. In our framework of scientific excellence, the Senior Scientist will be an active individual contributor to the design, execution, and interpretation of potency assays, as well as to the ongoing innovation by proposing, evaluating, and implementing innovative approaches in the field of potency assays. The successful candidate would have a deep understanding of underlying biological mechanisms and assay principles, with experience in key techniques, such as immunoassay platforms, stable cell line generation and/or cell-based assay development to assess the potency of drug candidates. Experience with multiple techniques and technologies, e.g. flow cytometry or lab automation, will be advantageous. The candidate will need to communicate results effectively, write technical reports, advise junior scientists, and participate in cross-functional teams. Experience of working in a GxP regulated laboratory environment for routine sample testing, documentation, and data verification will be a plus. Experience of working with novel biological drug modalities will be a plus.
Education Minimum Requirement:
Required Experience and Skills:
Preferred Experience and Skills:
NOTICEFORINTERNALAPPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
Pay Transparency Nondiscrimination
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.
Expected salary range:
$111,400.00 - $175,300.00
Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
Flexible Work Arrangements:
Not Applicable
Shift:
Valid Driving License:
Hazardous Material(s):
We are seeking a highly motivated Senior Scientist to join our Biologics Potency team within the Cell Based Sciences, Analytical Research and Development organization of our company's Research Laboratories at Kenilworth, NJ. The qualified candidate will be responsible for developing, establishing pre-qualification and robustness, and transferring immunoassays and cell-based potency assays to assess the biological activity of various biologics modalities such as antibodies, multifunctional proteins, peptide therapeutics, antibody-drug-conjugates, and novel biologics. In our framework of scientific excellence, the Senior Scientist will be an active individual contributor to the design, execution, and interpretation of potency assays, as well as to the ongoing innovation by proposing, evaluating, and implementing innovative approaches in the field of potency assays. The successful candidate would have a deep understanding of underlying biological mechanisms and assay principles, with experience in key techniques, such as immunoassay platforms, stable cell line generation and/or cell-based assay development to assess the potency of drug candidates. Experience with multiple techniques and technologies, e.g. flow cytometry or lab automation, will be advantageous. The candidate will need to communicate results effectively, write technical reports, advise junior scientists, and participate in cross-functional teams. Experience of working in a GxP regulated laboratory environment for routine sample testing, documentation, and data verification will be a plus. Experience of working with novel biological drug modalities will be a plus.
Education Minimum Requirement:
- Ph.D.,
- OR Master's Degree with a minimum of 5 years' experience,
- OR Bachelor's Degree with a minimum of 8 years' experience in cell biology, bioengineering, biological sciences, or related discipline in the biopharmaceutical industry.
Required Experience and Skills:
- Experience in cell-based bioassay development for biologics modalities such as monoclonal antibodies, multi-domain proteins, antibody drug conjugates, peptide-based therapies, or other novel biological modalities with deep understanding of underlying biological mechanisms and assay principles is highly desired.
- Experience in applying a variety of biochemical, biological, and immunological techniques (such as cell-based assays, ELISA, reporter gene assays, qPCR, or ADCC/CDC, etc.) as used for cell-based assay development.
- Experience working with BSL2 level biological agents
- A strong team player with excellent oral and written communication skills and ability to work independently.
- Strong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment.
Preferred Experience and Skills:
- Proficiency in utilizing statistical software for design of experiments and dose-response curve analysis (e.g. PLA, JMP, DoE, or SoftMax Pro).
- Experience with multiple techniques and technologies, e.g. flow cytometry, lab automation, or stable cell line generation, will be advantageous.
- Experience with assay qualification, validation according to ICH guidelines.
- Working knowledge of regulatory and industry guidelines in the area of potency assay development.
- Prior experience in working in and transferring assays to a regulated GxP testing facility will be valuable for the role.
- Experience of working on novel biological modalities will be a plus.
NOTICEFORINTERNALAPPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
Pay Transparency Nondiscrimination
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.
Expected salary range:
$111,400.00 - $175,300.00
Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
Flexible Work Arrangements:
Not Applicable
Shift:
Valid Driving License:
Hazardous Material(s):
