AddressDescription
Johnson and Johnson Innovative Medicine is seeking a Senior Associate Scientist to join the Clinical Assay Development group within the Oncology Translational Research Department in Spring House, PA to work in a hybrid capacity. The role will be responsible for delivering high priority fit-for-purpose biomarker assays to support Phase I through Phase III Oncology clinical studies and high-quality clinical data to enable clinical decision making and the advancement of Oncology drug development programs.
Principal Responsibilities
- Process human specimens (blood, bone marrow, and solid tissues) for downstream flow cytometry and molecular analysis.
- Analyze samples and data to characterize tumor cells, immune cell populations and cell lines by multiparameter flow cytometry and molecular assays.
- Perform routine tissue culture and maintenance of cell lines.
- Guide the assay development and transition of developed methods to internal or external labs for assay validation.
- Guide the assay validation and delivery of resulting validation reports from the clinical research organizations (CROs).
- Monitor data quality from the outsourced assays during clinical sample analysis.
- Record experimental data and results accurately following SOPs and internal document requirement.
- Collaborate and communicate with internal stakeholders, management, and external service providers to ensure project priorities are being met.
Qualifications
- A minimum of a Bachelor’s degree in Biology or a related scientific discipline is required.
- A minimum of 3 years of hands-on experience with multiparameter flow cytometry, including setting up instruments, sample preparation, data analysis, is required.
- Experience with flow cytometry clinical assay development and analytical validation within the healthcare industry or an academic setting is required.
- Experience with flow cytometry assay troubleshooting is required.
- Experience with aseptic technique, cell culture and cell-based assays is required.
- Molecular biology experience is required.
- Prefer a person with minimum of 2-3 years hands-on experience and understanding of routine modern molecular biology techniques including nucleic acid purification and quantification, qPCR, ddPCR, next generation sequencing etc.
- Experience writing validation reports is preferred.
- Must have excellent verbal and written communication skills.
- Must have excellent interpersonal skills, with the ability to interact effectively with people, internally and externally.
- The ability to effectively present scientific data and concepts to in-house research forums and outside professional meetings is required.
- The ability to collaborate with all levels of management across a matrix environment is required.
About Johnson & Johnson
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
