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SalaryCircle Pharma is a dynamic biotech company that has raised $160 million to date from industry-leading investors. We are transitioning into a clinical-stage company, and we’re currently developing a first-in-class precision oncology pipeline that addresses severe unmet medical needs by harnessing a novel, cell-permeable, oral macrocycle platform.
We seek candidates who desire to make key contributions to help drive our growth. For more information about Circle Pharma, please see our website, www.circlepharma.com.
We are seeking a highly talented and motivated Analytical Chemist to join our macrocycle drug discovery team at the Scientist II/Sr Scientist level. The successful candidate will lead the lab-based analytical and purification activities supporting our discovery programs. It’s critical that the candidate has a deep passion for drug discovery coupled with extensive hands-on expertise in analytical and purification method development.
What You'll Do:
- Lead in-house analytical and purification team to support small molecule / peptidic macrocycle drug discovery programs, while providing guidance and mentorship to junior scientists.
- Perform HPLC/UPLC, LCMS method development and analysis for purity assessment, identification of impurities, determination of chemical and formulation stability, and preparative scale purification.
- Manage outsourced analytical and purification activities as needed.
- Oversee analytical/purification instrumentations, coordinate troubleshooting, routine service and maintenance. Bring in new technologies and methodologies to expand capabilities and operational efficiency.
- Collaborate with cross-functional teams, including Chemistry, Biology, and DMPK, to align purification and analytical efforts with overall project goals.
- Provide regular updates to multidisciplinary teams and senior management. Lead or contribute to the writing of study reports, SOPs, scientific publications, and patent applications.
- Engage in laboratory bench work to support the development and training of junior scientists.
About You:
- PhD in relevant scientific area with 2+ years of relevant experience -or- BS/MS with 10+ years industry experience, coupled with clear professional achievements. More years of experience would qualify you as a Sr. Scientist.
- Strong leadership skills. Prior people management experience is required.
- Hands on experience with analytical techniques and related method development for small molecules/peptide and formulations required, including UPLC/HPLC, LCMS, and SFC. Experience with prep LC is required. Experience with troubleshooting and maintenance for UPLC/HPLC, LCMS, and prep LC or SFC is plus.
- Knowledge with small molecular/peptide drug discovery and early-stage development is a plus.
- Proven track record in applying analytical techniques to solve challenging problems.
- Self-directed and motivated.
- Collaborative and good team player.
- Strong organizational skills and communication skills.
- Enjoys operating in an exceptionally dynamic, highly productive, and cooperative environment where every voice matters.
- Demonstrated willingness to lead, champion, and operate with Circle’s Core Values.
The expected salary for a Scientist II in this role in South San Francisco, CA is $121,000 - $142,000, and for Sr. Scientists, it is $132,000 - $155,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, Circle’s internal pay equity, etc.
Circle Pharma recognizes that the success of our endeavors depends on the success of every team member. Your well-being is our top priority, and we are proud to offer a comprehensive total rewards package. Our benefits include but are not limited to medical, dental, and vision care. We also provide a 401(k) plan with a generous company contribution, and all of our offers contain a stock option component. We provide company-paid life insurance, short-term and long-term disability. Additionally, we provide many company-paid holidays, including a winter break at the close of the calendar year.
Circle Pharma is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, gender identity, disability status, membership in an organization or any other non-merit factors.
