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SalaryJob Summary
As a Research Scientist I, Immunology & Cell Biology, you will design, execute, analyze, and present the results of cell-based assays for testing activities and immunogenicity of natural and synthetic protein sequences.
Your primary responsibility is to develop and onboard assays that use mammalian cells to detect the activities of enzymatic proteins and quantify their immunogenic properties. You will also be heavily involved in the research and development cycle, regularly collaborating with computational scientists to generate optimal protein sequences for treating various pathological conditions.
Location: This is an in-person role, working onsite at our Chicago office.
What You’ll Do
- Collaborate with wet lab scientists, data scientists, and scientific leadership to design cell-based assays to test the activities and immunogenicity of the proteins relevant to the project.
- Culture and stain cell lines/primary cells for microscopy-based visualization, record phenotypic changes, and quantitatively analyze microscopic images to execute cell-based activity assays.
- Calculate and prepare antigen dilutions, plate and incubate antigens and cells, and visualize the immunogenic responses to perform immunogenicity assays using pre-genotyped human immune cells.
- Prepare quantitative summaries of results using data analysis and plotting software, document and present such results, and routinely maintain electronic records of all documents.
- Discuss your experimental workflows, share your results, and exchange ideas with team members and key stakeholders to advance project goals.
Who You Are
You thrive in an early-stage start-up environment where you can leverage your agility and expertise to deliver high-quality results. You are naturally curious and excel when working collaboratively to solve tough problems. You know when to implement advanced strategies and when an “if statement” is good enough. You have diverse technical skills and a drive for ongoing learning and development. You find satisfaction and motivation in your work, and you take the time to pursue your passions outside of the office.
Required Skills
- 1+ year(s) of industry experience working in Cell Biology and/or cellular/molecular immunology.
- Proven track record of working with mammalian cells (primary cells and/or cell lines), blood cells, or human immune cells such as PBMC, T-cells, or Dendritic cells.
- Expertise in standard tissue culture techniques such as ExpiCHO, HeLa, HEK, iPSC, or C2C12.
- Demonstrated expertise in microscopy-based imaging such as regular fluorescence and/or confocal microscopy, and quantitative image-analysis techniques using software like ImageJ, Imaris, or MetaMorph.
- Demonstrated experience in testing the immunogenicity of molecules using assays like ELISA, ELISpot, Fluorospot, DC-T, or MAPS.
- Proficiency in data analysis software, like Prism, Origin, or Matlab.
- Familiarity with interactive computing platforms like Python, R, Jupyter, or Notebooks.
- Experience using lab documentation software such as eLabNext or Confluence.
- Excellent scientific communication and data-presentation skills.
Education: Ph.D. in Cell Biology, immunology, or directly related areas or equivalent skills and knowledge gained through sufficient industry experience.
Preferred Skills
- Experience in developing and/or executing cell-based high throughput assays for screening protein activities, using techniques like Flow Cytometry (FACS) and/or multiplexed assays such as BioPlex or Luminex.
- Experience working with live animal models such as mice, rats, hamsters, rabbits, or non-human primates.
- Experience with or exposure to automated liquid handling systems like Tecan or Echo.
- Familiarity with Next Generation Sequencing platforms and/or data.
- Participation in IND-enabling studies for potential therapeutics.
- Involvement and/or participation in science and technology community forums, events, conferences, or outreach programs.
Please include your list of publications in relevant scientific areas on your resume.
