Address
Form of workAbout Acrivon Therapeutics, Inc.
Acrivon (NASDAQ: ACRV) is a clinical stage biopharmaceutical company developing precision oncology medicines that it matches to patients whose tumors are predicted to be sensitive to each specific medicine by utilizing Acrivon’s proprietary proteomics-based patient responder identification platform, Acrivon Predictive Precision Proteomics, or AP3. The AP3 platform enables the creation of drug-specific proprietary OncoSignature® companion diagnostics that are used to identify the patients most likely to benefit from Acrivon’s drug candidates, referred to as patient responders. The name Acrivon (derived from Greek for “accurate”) embodies how our OncoSignature® tests link the patient’s active tumor-driving mechanisms with the drug’s mode-of-action to accurately match our therapies with patients who will benefit independent of underlying genetic tumor alterations.
Acrivon is currently advancing its lead candidate, ACR-368, a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types, which the AP3 platform predicts will have a high proportion of patient responders based on OncoSignature®-predicted sensitivity to ACR-368. In addition to ACR-368, Acrivon is also developing internally-discovered preclinical stage pipeline programs targeting critical nodes in the DNA Damage Response, or DDR, and cell cycle regulation pathways, including WEE1, a protein kinase, and PKMYT1, a closely related protein serine/threonine kinase.
Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.
Position Overview:
The Research Associate/Senior Research Associate will be a key member of Acrivon Therapeutics’ Research and Development team, involved in various aspects of biomarker discovery, selection and screening. The candidate will actively participate in the development of drug-tailored OncoSignature® tests for patient selection.
This position will be located at our US headquarters in Watertown, MA.
Responsibilities:
- Conduct translational research studies using in vitro and in vivo models, archival tissues, and archival patient samples.
- Engage in biomarker discovery and characterization.
- Contribute to and participate in assay development.
- Contribute as a member of a diverse and motivated team of researchers.
- Document, compile, and interpret experimental data.
Qualifications:
- BS/MS in Biological Sciences or in a related discipline.
- 2-4 years of laboratory experience in academia or industry. Previous experience in cancer research is highly desirable.
- Broad cell and molecular biology laboratory skills such as cell-based assays, Mammalian tissue culture, SDS-Page and Western Blot, RT-PCR.
- Experience in fluorescence microscopy, image analysis software usage and data analysis and interpretation.
- Knowledge and experience in immunohistochemistry/immunofluorescence is highly desirable.
- Experience in histology is a plus.
- Drug development experience is a plus.
- Excellent communication and organizational skills and working knowledge of Microsoft Office.
- Strong ability to analyze, summarize and document data and work collaboratively as a team player.
Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.
