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SalaryPliant Therapeutics is a late-stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by fibrotic diseases. As the leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, Pliant is developing small molecule drug candidates specifically designed to impact the fibrotic process.
The Company's lead product candidate, bexotegrast (PLN-74809), is an oral small molecule, selective inhibitor of the αvβ1 and αvβ6 integrins that play a key role in multiple fibrotic pathways. Bexotegrast has received Fast Track Designation and Orphan Drug Designation from the U.S. Food and Drug Administration for both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC) and Orphan Drug Designation from the European Medicines Agency in IPF and PSC. Pliant is currently conducting BEACON-IPF, a Phase 2b trial of bexotegrast for the treatment of IPF and INTEGRIS-PSC, a Phase 2a trial of bexotegrast for the treatment of PSC.
Pliant has also developed PLN-1474, a small molecule, selective inhibitor of αvß1 for the treatment of nonalcoholic steatohepatitis, or NASH with liver fibrosis. Pliant is conducting a Phase 1 study for its third clinical program, PLN-101095, a small molecule, dual-selective inhibitor of αvß8 and αvß1 integrins, that is being developed for the treatment of solid tumors. The Company also has discovery and development programs in oncology and muscular dystrophies.
Description
Pliant is seeking a talented and highly motivated individual with a strong background in Analytical Chemistry to join our chemistry team in the pursuit of novel small molecules to treat fibrotic disease. The R&D Manager, Analytical Chemistry is responsible for independently performing routine and non-routine analytical testing of novel chemical entities in our state-of-the-art analytical lab. The successful candidate will have familiarity with multiple analytical techniques critical for the purification and identification of novel chemical entities and have strong problem-solving abilities.
Responsibilities
- Demonstrated experience with chromatographic purification and compound characterization
- Manage, operate, and maintain analytical laboratory equipment including UPLC-MS, SFC, HPLC, and mass-directed purification systems
- Implement and contribute to the development of analytical and purification methods as required for high throughput chemistry libraries
- Conduct in-vitro ADME assays for permeability
- Provide regular progress updates to the chemistry team
- Maintain an accurate and detailed electronic lab notebook
- Manage and develop junior lab personnel to high levels of productivity
Qualifications
To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, abilities and prior experience required.
- BS in chemistry or related field with 10+ years of relevant experience in Analytical Chemistry or MS with 8+ years of relevant experience in Analytical Chemistry.
- A minimum of 2 years managing a direct report is required.
- Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
- Excellent troubleshooting skills and perceptive mechanical problem-solving ability.
- Experience with small molecule purification equipment and procedures using UV and/or MS-directed prep-HPLC. NMR experience is a plus.
- Enthusiastic and self-motivated with effective time management skills.
- Ability to work independently and perform well in a team environment.
- Ability to thrive in a culture of respect, accountability, transparency, and collaboration.
Pliant requires all new hires to be fully vaccinated prior to the first date of employment (subject to any legally required exemptions).
The annual base salary for this role is $155,000 - $162,000. Individual pay may vary based on additional factors, including, and without limitation job-related skills, experience, work location and relevant education or training. Pliant's compensation package also includes benefits, equity, and annual target bonus for fulltime positions.
To understand how Pliant complies with and manages your personal information with respect to the California Consumer Privacy Act, please visit https://pliantrx.com/ccpa-applicant-and-staff-privacy-notice/.
