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6000! That's the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
NIBR Emeryville, California, houses approximately 170 associates and includes Novartis Institute for Tropical Diseases (NITD), an independent research institute within NIBR that applies drug discovery expertise to combat infectious tropical diseases. In addition, a protein interactomics drug discovery center has been formed at this site and includes medicinal chemistry, computer-assisted drug discovery, structural and biophysical chemistry, protein sciences, compound management, and analytical chemistry. Located in the heart of a key academic and biotechnology center, NIBR Emeryville collaborates with local institutions such as Stanford and the University of California campuses in Berkeley and San Francisco.
The Analytical group within Global Discovery Chemistry is seeking a highly skilled scientist with demonstrated experience in the implementation and use of protein structural MS. This will include native MS, hydrogen-deuterium exchange MS, hydroxyl radical protein footprinting, ion mobility MS and proteomics. The selected individual will apply structural MS techniques to investigate protein ligand interactions and elucidate the structure of macromolecular assemblies, including soluble and membrane protein complexes. Scientific curiosity, self-motivation, attention to detail, and strong communication skills are required.
Your responsibilities will include, but not be limited to:
•Apply structural MS to study noncovalent interactions between proteins and their binding partners including other proteins, nucleic acids, lipids, carbohydrates, and small molecules.
•Determine the mass of intact protein assemblies, their stoichiometry, interactions between subunits, the relative position of subunits within an assembly, and the strength of inter-subunit interactions.
•Combine HDX MS, native MS, and ion mobility to study the shape and dynamics of protein complexes and protein conformers
•Develop workflows for bottoms-up proteomics sample preparation, MS acquisition and data analysis approaches
•Evaluate opportunities and when applicable, implement new analytical technologies and software to improve efficiency or reduce operating costs.
•Collaborate with IT and automation groups to develop and enhance the capabilities of the current infrastructure to adjust to changing lab demands.
•Collaborate with equipment vendors for new instrument purchasing and advancement of capabilities.
Minimum requirements
What you'll bring to the role:
•PhD in the biological sciences, chemistry or related field with at least 2 years of relevant structural MS experience in either an academic or industry setting.
•Solid background in analytical chemistry, Mass Spectrometry, protein biochemistry, and separation science.
•Strong hands-on experience with the operation and troubleshooting of mass spectrometers used for structural MS and related automation equipment.
•Strong written and verbal communication skills are essential, along with the ability to work effectively on matrix teams.
Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
The pay range for this position at commencement of employment is expected to be between $102,400 and $153,600 however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
6000! That's the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
NIBR Emeryville, California, houses approximately 170 associates and includes Novartis Institute for Tropical Diseases (NITD), an independent research institute within NIBR that applies drug discovery expertise to combat infectious tropical diseases. In addition, a protein interactomics drug discovery center has been formed at this site and includes medicinal chemistry, computer-assisted drug discovery, structural and biophysical chemistry, protein sciences, compound management, and analytical chemistry. Located in the heart of a key academic and biotechnology center, NIBR Emeryville collaborates with local institutions such as Stanford and the University of California campuses in Berkeley and San Francisco.
The Analytical group within Global Discovery Chemistry is seeking a highly skilled scientist with demonstrated experience in the implementation and use of protein structural MS. This will include native MS, hydrogen-deuterium exchange MS, hydroxyl radical protein footprinting, ion mobility MS and proteomics. The selected individual will apply structural MS techniques to investigate protein ligand interactions and elucidate the structure of macromolecular assemblies, including soluble and membrane protein complexes. Scientific curiosity, self-motivation, attention to detail, and strong communication skills are required.
Your responsibilities will include, but not be limited to:
•Apply structural MS to study noncovalent interactions between proteins and their binding partners including other proteins, nucleic acids, lipids, carbohydrates, and small molecules.
•Determine the mass of intact protein assemblies, their stoichiometry, interactions between subunits, the relative position of subunits within an assembly, and the strength of inter-subunit interactions.
•Combine HDX MS, native MS, and ion mobility to study the shape and dynamics of protein complexes and protein conformers
•Develop workflows for bottoms-up proteomics sample preparation, MS acquisition and data analysis approaches
•Evaluate opportunities and when applicable, implement new analytical technologies and software to improve efficiency or reduce operating costs.
•Collaborate with IT and automation groups to develop and enhance the capabilities of the current infrastructure to adjust to changing lab demands.
•Collaborate with equipment vendors for new instrument purchasing and advancement of capabilities.
Minimum requirements
What you'll bring to the role:
•PhD in the biological sciences, chemistry or related field with at least 2 years of relevant structural MS experience in either an academic or industry setting.
•Solid background in analytical chemistry, Mass Spectrometry, protein biochemistry, and separation science.
•Strong hands-on experience with the operation and troubleshooting of mass spectrometers used for structural MS and related automation equipment.
•Strong written and verbal communication skills are essential, along with the ability to work effectively on matrix teams.
Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
The pay range for this position at commencement of employment is expected to be between $102,400 and $153,600 however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
