Principal Scientist, Cell Line Development

Job Description

We are recruiting a Principal Scientist to join the Cell Line Development helping to advance our Company’s biologics pipeline portfolio. The individual will play a critical role in the delivery of biologics pipeline using innovative thinking, state-of-the-art platform technologies and fit-for-use methodology. Candidate should demonstrate and stay up to date on the knowledge of principles and theories related to protein engineering and expression technologies. Candidate should be knowledgeable and experienced in end-to-end Cell Line Development, cell banking, process development and IND/BLA filing to provide a line of sight of manufacturing, scale-up, and commercialization.

Primary Responsibilities

• The successful candidate should have strong knowledge related to commercial Chinese Hamster Ovaries Cell Line Development. Candidate must have deep subject matter expertise in Cell Line Development and broad experience in biologic drug development. The candidate must have direct experience with molecular techniques and mammalian culture. The candidate should demonstrate and stay up to date on the knowledge in genomics, transcriptomics, proteomics and genome editing technologies.

• Collaborates effectively with process development, Discovery, Enabling Technologies, Analytical R&D, Quality, and other of our Company's partner groups to provide innovative and practical solutions to ensure successful drug substance deliveries under tight timelines.

• Primary duties will include developing and characterizing stable mammalian Cell Line suitable for biomanufacturing.

• Serve as the subject matter expert in Cell Line Development and technical lead to represent functional area for biologics pipeline programs.

• Complete and effectively manage multiple projects within timelines ensuring that all tasks and responsibilities are carried out according to high scientific and ethical standards.

• Responsible for technical reports and relevant sessions of Investigational New Drug (IND) and BLA filings

• Publications in peer-reviewed scientific journals and external/internal presentations are expected.

Minimum Education required:

• PhD in Molecular Biology, Cell Biology, Genetics or related Biological Sciences with 5 + years of Cell Line Development or related experience

Experience | Skills | Knowledge:

• Strong knowledge and record of scientific skills in vector optimization and/or CHO host cell engineering

• Must have a strong track record of delivering results via innovation and fearless problem-solving.

• Excellent interpersonal, communication, negotiating, influencing, and collaboration skills.

• demonstrated technical/scientific excellence through publications/presentations.

• Experienced in project managing and ensure timely communication between CLD and other functional areas within CMC Team

• Experienced in IND/BLA filing and preparing relevant documentation.

• Effective verbal and written communication

Preferred experience and skills:

• Experienced in next generation sequencing (NGS), System Biology (e.g. transcriptomics, proteomics)

• Experienced in flow cytometry.

• Familiarity with development of computational tools in biology that use genomic data to generate biological hypothesis.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:

$149,400.00 - $235,100.00

Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

biohazard

Requisition ID:R281254