Postdoctoral Fellow In Translational Neuroscience

SHIFT:
Day (United States of America)
Seeking Breakthrough Makers
Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.
At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.
CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.
We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.
A Brief Overview
Will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
A Postdoctoral Fellow position is available in the laboratory of Dr. Xilma Ortiz-Gonzalez at the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania (UPenn). Our laboratory uses a range of molecular and cellular biology, human cellular disease models (IPSc-derived neurons), and live imaging technologies to study the underlying disease mechanisms of monogenic pediatric neurodevelopmental and neurodegenerative disorders. The candidate will work closely with the other members of our diverse and vibrant research team. Publications we would like to highlight include:
• Shieh JT, Tintos-Hernandez JA, Murali CN, Penon-Portmann M, Flores-Mendez M, Santana A, Bulos JA, Du K, Dupuis L, Damseh N, Mendoza-Londoño R, Berera C, Lee JC, Phillips JJ, Alves CAPF, Dmochowski IJ, Ortiz-González XR. Heterozygous Nonsense Variants in the Ferritin Heavy Chain Gene FTH1 Cause a Neuroferritinopathy.HGG Adv. 2023 Sep 1;4(4):100236. doi: 10.1016/j.xhgg.2023.100236. [Epub ahead of print] PubMed PMID:37660254; PubMed Central PMCID: PMC10510067.
• Tintos-Hernandez JA, Santana A, Keller KN,Ortiz-Gonzalez XR. Lysosomal dysfunction impairs mitochondrial qualitycontrol and is associated with neurodegeneration in TBCK encephaloneuronopathy.Brain Commun. 2021;3(4): doi:10.1093/braincomms/fcab215. PubMed PMID: 34816123
• Abdelmoumen I, Jimenez S, Valencia I, Melvin J, Legido A, Diaz-Diaz MM, Griffith C, Massingham LJ, Yelton M, Rodríguez-Hernández J, Schnur RE, Walsh LE, Cristancho AG, Bergqvist CA, McWalter K, Mathieson I, Belbin GM,Kenny EE,Ortiz-Gonzalez XR, Schneider MC. Boricua Founder Variant in FRRS1LCauses EpilepticEncephalopathy With Hyperkinetic Movements.J Child Neurol. 2021 Feb;36(2):93-98. PubMed PMID: 32928027.
• Ortiz-González XR, Tintos-Hernández JA, Keller K, Li X, Foley AR, Bharucha-Goebel DX, Kessler SK, Yum SW,Crino PB, He M, Wallace DC, Bönnemann CG. Homozygous boricua TBCK mutation causes neurodegeneration and aberrant autophagy.Ann Neurol. 2018 Jan;83(1):153-165. PubMed Central PMCID: PMC5876123.
Faculty page: https://www.med.upenn.edu/apps/faculty/index.php/g324/p8165073 Lab website: https://www.med.upenn.edu/oglab/
Full publication list:
https://www.ncbi.nlm.nih.gov/myncbi/xilma.ortiz-gonzalez.1/bibliography/public/
Role of Rare Disease Community and Underserved Populations in our work: https://www.research.chop.edu/cornerstone-blog/community-at-center-of-rare-disease-research-for-tbck-syndrome. More links to press coverage of our work available on our lab website
CHOP is an equal-opportunity employer. Postdoctoral fellows are provided with comprehensive benefits packageincluding eligible health insurance and retirement plan ( http://www.research.chop.edu/careers/working-research/benefits-information). CHOP and UPenn offer outstanding research and training environments. The lab is fully committed to the success and career development of every team member. Previous team members are currently working in both academic (universities, hospitals, etc.) and industry (pharmaceutical, biotech, etc.) positions.
What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

• Doctorate Required