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Form of workJob Description
Gate Bioscience is a venture-backed, preclinical biotech company creating a new class of medicines called Molecular Gates. Our therapeutics are small molecules that aim to cure diseases by selectively eliminating harmful extracellular proteins at their origin: inside the cell. Every extracellular protein—of which there are more than 4,000—must pass through a single channel in the cell before it can be secreted into the body. Molecular Gates bind to this channel, setting up a “gate” that recognizes and blocks a specific, disease- causing protein from exiting. With nowhere to go, the protein is degraded instead of being secreted. By eliminating the harmful protein at the source, Gate aims to eliminate the disease for patients. Founded in 2021, Gate is backed by Versant Ventures, a16z Bio + Health, ARCH Venture Partners, and GV. Learn more at www.gatebio.com.
The Role:
The Medicinal Chemist role is a growth opportunity for an independent and creative scientist to lead a core drug discovery project from early discovery to clinical candidate. The ideal candidate will be a natural scientific leader able to run a complex project including managing external chemistry resources, while simultaneously collaborating closely with a multidisciplinary internal drug discovery team.
In this role you will:
• Leverage expertise in synthetic organic chemistry to drive the SAR optimization cycle to identify development candidates.
• Conceive and execute Medicinal Chemistry research and development to achieve project and company goals.
• Act as a project team leader in your area of expertise as part of a collaborative team on one or more discovery research projects.
• Generate Medicinal Chemistry proposals and guide execution at external contract research organizations.
• Critically evaluate scientific advances and assess relevance and application to on-going research programs.
What to expect if you join us:
In the first month, you will work closely with members of the project teams to learn about on-going and future programs including biological assays, current workflow and the Gate Bioscience platform for interrogating Molecular Gates.
By three months, you will be independently designing, synthesizing and proposing new compounds to expand the SAR understanding of programs as well as utilizing the platform to design diversity libraries to support future new
lead identification. You will also collaborate with a biology counterpart in prioritizing compounds for ADME, in vitro toxicological, and in vivo profiling to make quick go/no-go decisions.
By six months, you will be independently leading a project team in collaboration with a biology counterpart, you will be responsible for setting project meeting agendas, budgets, and delivering on company goals.
Required Skills:
• Creativity, productivity, and independence in the lab to deliver key advances in SAR understanding and enable the success of your project.
• Demonstrate the ability resolve key project hurdles by effectively using available information and technical expertise.
• Experience using SBDD and chemoinformatic tools to guide design of small molecule drugs.
• Experienced at project leadership, including setting relevant project goals, managing internal & external resources, collaborating with and communicating effectively to other stakeholders.
• Effectively communicate research results and relevant project information across the company.
• Energized by a fast-paced and collaborative work environment, with a willingness to take on new tasks to further company goals.
Education:
Ph.D. in Organic or Medicinal Chemistry, or related fields, with 4-8 years of
relevant research experience in industry or academia.
Compensation:
Below is the expected salary range for this position. Individual compensation is based on various factors, including level, experience, education, skill set, and geographic location. This range is for our San Francisco Bay Area, location and may be adjusted to the labor market in other geographic areas.
Target Salary Range: $116,000 - $201,000
In addition to salary, Gate Bioscience offers equity in the company, a robust benefits package, 401(k) program with employer match, and the opportunity to be a part of ground-breaking research.
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