DMPK Principal Scientist

Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our lab in San Diego is looking for a motivated and versatile Drug Metabolism and Pharmacokinetics (DMPK) Principal Scientist or Associate Director to join our team to help advance our compounds through preclinical and clinical development. The successful candidate will be driving the overall PKPD modeling and simulation (M&S) effort to support projects from early research through early clinical development.

This is a full-time position in a fast-paced biotech environment with a collegial group of high-level colleagues working towards well-defined goals. Full medical and dental benefits, flexible work hours/vacation included in this opportunity to learn all aspects of biotech start-up.

Learn more about us here: https://www.genesistherapeutics.ai/

And our recent collaboration with Eli Lilly here: https://endpts.com/genentech-partnered-genesis-therapeutics-inks-newest-ai-discovery-deal-with-eli-lilly/

What You Will Do (Key Responsibilities):

• Interpret pharmacokinetic and pharmacodynamic data (PK/PD modeling, PBPK, human dose prediction, etc..) to inform the design of preclinical pharmacology, toxicology, and clinical studies.  
• Partner with AI engineer on ADME predictive model
• Represent DMPK as the technical expert on project teams, providing scientific and strategic leadership for all stages of drug discovery and early development.
• Preparation of nonclinical DMPK/ADME reports and document for candidate nomination and regulatory filing. 
• Collaborate and communicate across departments and participate on drug discovery project teams.

What you'll bring:

• A Master's or Ph.D. in Pharmaceutics, Pharmacokinetics, Pharmacology, Biomedical engineering or related discipline with 8+ years Industrial experience in Drug Discovery & Development.
• Experience in the conduct, analysis, and interpretation of in vivo pharmacokinetics and PKPD studies.
• Prior experience in modeling and simulation using Phoenix, MatLab, Berkeley-Madonna, R, NONMEM, or related softwares. 
• Knowledge on various in-vitro & in vivo ADME assays.   
• Ability to conduct self-directed research and to work effectively in a dynamic environment with diverse team of coworkers.
• Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.

What we offer:

• Competitive Pay
• Stock Option
• Eligibility401(k) Plan
• Open PTO Policy
• Paid Company Holidays
• Free lunch and snacks at our offices
• Health Care Plan, including Medical, Dental, and Vision, fully covered for the employees

Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.

Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. 

The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has two AI platform collaborations across a range of therapeutic areas: Eli Lilly (signed in 2022, with a $20M upfront payment and a $670M total deal size), and Genentech (signed in 2020).

We raised a $200M series B in August 2023, and have raised over $280M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures. 

Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.