Director, Ta Genetics - Neuro/Ophth

We are looking for an applied computational biologist and geneticist to join our Neuroscience & Ophthalmology Therapeutic Area Genetics team. The position will take on responsibilities for the design, execution, and interpretation of genetics studies focusing on neurological, ophthalmological, and auditory diseases. This role will function in collaboration with the Analytical Genetics, Clinical Informatics, and Genome Informatics to lead genetics discovery projects, support both new programs/collaborations, and the execution of overall scientific strategy. Goals of the team include identification of novel drug targets, supporting existing drug targets, and using genetics data to optimize translational science, e.g. by informing patient stratification or biomarker selection.
A day in the life of a Director - Therapeutic Area Genetics may look like:

• Analysis and interpretation of large-scale genomics and other omics datasets from sequence data to association, with aid of in-house pipelines and supporting scientists to facilitate projects.
• Development of efficient workflows (formal and informal) to analyze genotype-phenotype associations and interpret results for biological interpretation.
• Work with a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, statistical geneticists, and other required staff to design, complete, and interpret genetics studies related to neurological diseases for the Center. Collaborate with external partners and internal Regeneron scientists in such efforts.
• Work with research and clinical colleagues at Regeneron to introduce human genetics evidence and studies into current research plans and to support drug development efforts.
• Provide human genetics expertise and consult on projects within other R&D departments at Regeneron including therapeutic focus area teams in Neuroscience, precision medicine, and early and late clinical development.

In Order to be considered qualified, you must have:
A PhD with at least 10 years of post-graduate experience in human genetics research and a translational genetics focus. Additional requirements include:
- Proficiency in python, R, or other interpretive languages. Additional background in linux, C, SQL, or WDL is a plus.
- Experience with statistical analysis of data from multiple platforms (chip-based genotyping, WES & WGS, Sanger, custom capture targeted sequencing, etc) as well as other genomic profiling technologies (microarrays, RNASeq, etc).
- Experience working on cloud computing interfaces with large-scale datasets such as UKB, FinnGen, or AllOfUs.
- A preference for prior experience in genetics studies of neurological, ophthalmological, or auditory phenotypes and interpreting rare variation.
- Experience leading a breadth of study designs and analyses spanning family and Mendelian studies, population genotype-phenotype association studies, etc. to deliver novel, medically interpretable genetic findings.
- Preferred: experience with genetic analyses involving complex loci (e.g. HLA, 17q21.31) and relevant methods and tools.
- Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations (eQTL, pQTL, etc).
- Familiarity with clinical genetics and various genetic models of disease.
- Motivated colleague with a desire to pursue genetic discovery in a goal-oriented, multi-disciplinary environment.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.
Salary Range (annually)
$198,000.00 - $330,000.00