Associate Scientist, In Vivo Pharmacology (Contract)

Associate ScientistIn Vivo Pharmacology (Contract Position)
This is what you will do:
You will be working under the supervision of the In Vivo Pharmacology Group Leader and will primarily be responsible for generating pre-clinical In Vivo data by testing novel small molecule therapies and immunotherapies in clinically relevant mouse cancer models. The role involves supporting primary pharmacology and translational pharmacology programs by identifying and characterizing new cancer therapeutics using various cell lines and genetically engineered In Vivo models. This person will determine the optimal doses, routes of administration and dose schedules, prioritize indications, identify biomarkers, elucidate mechanisms of resistance and identify efficacious combinations. The daily activities will include implanting, ear tagging, measuring, and dosing (PO, IP, IV) of various mouse cancer models, collecting tissues, formulating drugs, and providing in vitro and ex vivo support.
You will be responsible for:

• Supporting drug discovery projects with relevant In Vivo assays and generating primary data packages.
• Executing In Vivo Pharmacology studies in mice (tumor growth inhibition, pharmacodynamic, pharmacokinetic and novel model growth curves).
• Use gain-of-function (over expression) and loss-of-function (RNAi, CRISPR/Cas) approaches to study gene function in various In Vivo models.
• Identifying effective combinations with chemotherapies, targeted therapies or immune-modulatory agents.
• Identifying clinically-tractable biomarkers that may guide patient selection or early-stage drug development.
• Maintaining vivarium equipment, detailed laboratory files and an electronic notebook.
• Presenting in lab meetings to inform and discuss progress, results and future studies.

You will need to have:

• A Bachelor's degree in a science-related field with direct animal research or two-years of
  direct animal research experience with no degree required
• Experience in rodent handling and procedures, especially in cancer pharmacology
• Experience in general laboratory techniques
• Highly organized with excellent communication skills
• Expertise in Microsoft Office Suite
• Must be willing to work off-hours, weekends and holidays at times to support research needs.
• The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

Why Join?
At Mirati, we have an unapologetic and relentless focus on our mission to transform the lives of patients with cancer and their loved ones. Patients and their families motivate us to work smarter, faster and better. We are driven by the knowledge that our efforts can one-day deliver life-saving therapies for the people who need us most. Urgency, open-mindedness, accountability and collaboration ground our work. These shared values are central to who we are, what we do and how we do it.
Our people fuel our success. They are fearless and passionate in their daily pursuit of our mission. We are committed to continuing to create a company and experience that attracts and keeps the best people. When you want your days to count and the work you do to matter, discovering and delivering potentially life-changing therapies is more than a job, it's the chance to be part of something bigger.
We believe diverse professional experiences and an inclusive culture can drive better outcomes for patients. We want employees to be authentic and use their perspectives to contribute to our mission in a meaningful way.
Mirati cultivates an environment where:

• An entrepreneurial attitude is encouraged
• Our people are empowered to speak up, embrace the gray and achieve solutions
• Diverse experiences are an important of part making the best decisions
• We laugh and have fun as a work family

No matter the role, we are unified by our passion for helping patients, and are inspired by a single vision - to unlock the science behind the promise of a life beyond cancer. Together, we own Mirati's success.
Mirati is proud to be an Equal Opportunity Employer. We embrace diversity and do not make decisions about employment, compensation, promotion, and other terms and conditions of employment based on race, color, religion (including religious dress and grooming practices), sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), sexual orientation, age, ancestry, national origin (including language use restrictions and possession of a driver's license issued under Vehicle Code section 12801.9), marital status, registered domestic partner status, reproductive health decision making, military and veteran status, physical or mental disability, medical condition, gender (including gender identity, gender expression and gender transitioning), genetic information, weight, or other basis protected by federal, state or local law or ordinance or regulation. Mirati is committed to providing a work environment free of harassment, discrimination, retaliation and disrespectful or other unprofessional conduct based on those characteristics, or based on the perception that anyone has any of those characteristics or is associated with a person who has or is perceived as having any of those characteristics.
Notice to Third Party Agencies: Please note that Mirati Therapeutics Inc. does not accept unsolicited resumes from recruiters or employment agencies.