Accounting Manager - R&D (Hybrid)

At 4D Molecular Therapeutics, Inc. (“4DMT”), we boldly innovate to unlock the full potential of genetic medicines for countless patients. We are committed to breaking boundaries and daring to cure as we develop new and foundational products and product components through our growing technology platforms.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.  

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators: 

•    Fully integrated clinical-phase company with internal manufacturing
•    Demonstrated ability to move rapidly from idea to IND
•    Five candidate products in the clinic and two declared pre-clinical programs
•    Robust technology and IP foundation, including our TVE and manufacturing platforms
•    Initial product safety and efficacy data substantiates the value of our platforms
•    Opportunities to expand to other indications and modalities within genetic medicine

GENERAL SUMMARY: 

The Accounting Manager – R&D will join the finance and accounting team, working with multiple cross-functional teams, including but not limited to clinical and pre-clinical R&D and technical operations/CMC. The ideal candidate will be hands-on and responsible for managing clinical trial, program, and functional budgets, preparing detailed accruals, and reviewing and analyzing contracts. 

*This is a Hybrid role requiring 1-3 days a week in office work. Bay Area based candidates required.*

RESPONSIBILITIES:  

• Partner with our Clinical, FP&A, CMC, and Research teams to ensure completeness and accuracy of Clinical Trials expenses 
• Establish relationships with our external CROs and other Clinical Trial and CMC vendors to ensure accurate and timed monthly reporting 
• Work closely with the clinical and procurement team to ensure all executed R&D contracts have been entered as purchase orders in the ERP 
• Review and track Clinical Trials and CMC agreements 
• Assist with the month-end close for Clinical and CMC, including accruals, prepayments, recording journal entries, and balance sheet accounts reconciliations 
• Assist with trend and variance analysis for Clinical and CMC costs and balances 
• Develop and maintain financial reports, including monthly and quarterly financial packages with variance reporting to budget and prior periods 
• Manage financial models for R&D pipeline programs to support decision-making and provide key insights 
• Ensure compliance with SOX policies and procedures 
• Assist with external audit requests and PBC items for quarterly and year-end audits 
• Participate in other ad-hoc projects and analyses as needed. Other duties as assigned: nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time 

QUALIFICATIONS: 

Education: 

• Minimum bachelor’s degree with a business, finance, or accounting major. 

Experience: 

• 5 - 7 years of accounting experience in the biotechnology/pharmaceutical industry 

Skills: 

• Proficiency with Excel to organize and analyze data. 
• Strong time-management skills and ability to prioritize and multitask. 
• Self-starter attitude with the ability to approach challenges and urgent requests with a positive, problem-solving mindset. 
• Strong interpersonal, verbal, and written communication skills. 
• Ability to build and maintain strong working relationships.

Base salary compensation range:

Bay Area Range:  $109,000/yr - $134,000/yr

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities