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About OmniAb
OmniAb provides our pharmaceutical industry partners access to the most diverse antibody repertoires and cutting-edge screening technologies to enable discovery of next-generation therapeutics. We leverage our state-of-the-art technologies to facilitate the discovery of best-in-class antibodies. Within OmniAb are also core capabilities for the discovery and screening of high-value ion channel and transporter targets.
OmniAb consists of dynamic, collaborative, and innovative team members that are passionate about contributing to the technological frontier of drug discovery and to the advancement of global human health. Together, with our partners, we are enabling the discovery of next-generation therapeutics.
About Our Internship Program
Our interns provide valuable support to our teams as we work to expand access to the most diverse antibody repertoires and cutting-edge screening technologies.
Our mission is to provide a welcoming environment and impactful work to our interns as well as learning and development opportunities. This is a 10-week program which offers an internship project and a platform for our interns to share their work with the organization. Our interns will be encouraged to drive their projects and network within the organization, but they will also have a dedicated Intern Manager and Intern Advocate to offer guidance and support throughout the program.
About This Role
We’re seeking a Summer Intern, SPR Analysis, who will be responsible for generating label-free biosensor interaction analysis that can help us understand key differentiating attributes of our in-vivo antibody platforms and train our AI tools to navigate these vast, diverse, naturally optimized immune repertoires to identify superior clones than those from conventional phenotypic screens. The individual will work within our Protein Sciences team, which focuses on cloning, expression, purification, and biophysical characterization of antibodies sourced from our in-vivo immune repertoires. This group also generates custom antigens to serve as immunogens and screening reagents to support antibody discovery. This individual will collaborate with the Antibody Discovery and Bioinformatics groups.
The ideal candidate has experience in protein sciences, biochemistry or molecular biophysics and is familiar with binding assays such as ELISA or more sophisticated instrument-based methods for interaction analysis such as BLI, SPR, ITC, FRET, stopped flow fluorescence, or enzyme kinetics.
This role reports to the VP, Exploratory Research.
Please note: Our program will begin mid-June and end mid-late August. This is an onsite position based out of our Emeryville headquarters, and we do not offer relocation for this opportunity. This is a full-time position, and the working hours are 8am-5pm (PT).
What You’ll Do
Learn the basics of biomolecular interaction analysis, as applied to characterizing therapeutic antibodies.
Learn best practices for designing high quality and reliable biosensor assays using SPR technology.
Design, perform and analyze assays relevant to the characterization of therapeutic antibodies, including kinetic and epitope binning assays.
Merge data with orthogonal data such as sequence and developability assessment to contextualize antibody binding properties within and across repertoires.
Investigate important questions that help us identify differentiating features of our in-vivo-sourced antibody repertoires and guide us towards the best clones, including:
Can AI augment affinity selections of single domain antibodies beyond those from conventional phenotypic screening?
Can very small binding domains achieve epitope diversity beyond what can be achieved from other antibody modalities?
Present your work at the annual Internship Showcase.
What You Bring
Currently pursuing a MSc or PhD in Molecular Biophysics, Biochemistry, Chemistry, Pharmacology, Immunology or a related field.
Proficiency in basic lab skills.
Experience in protein science and basic protein characterization methods.
Ability to work both independently and deliver responsibilities within a highly collaborative environment.
Nice To Have
Foundational understanding of protein biochemistry.
Experience using instrumentation for characterizing biophysical properties of proteins.
Experience using label-free biosensor technologies for biomolecular interaction analysis.
The base compensation range for this position is $30-$45 per hour. The range provided is an estimate. Actual compensation may vary based on skills, experience, education, location, and other factors permitted by law.
At OmniAb, we value diversity and strive to create an inclusive environment for everyone. We welcome a variety of experiences, skills, and perspectives within our organization and encourage individuals from diverse backgrounds to apply. We’re proud to be an Equal Opportunity Employer, and we will consider all qualified applicants based on merit and business need. We do not discriminate due to any non-merit-based factors or legally protected classes under federal, state, or local law.
