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Form of workAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
Position Summary:
The Senior Principal Scientist / Scientific Lead in the Discovery Technologies In vivo Pharmacology group will be part of a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. The candidate will collaborate with discovery teams in NYC, Indianapolis, San Francisco and Boulder for design and execution of studies. The In vivo Pharmacology Scientist will design and execute experiments, and will also be responsible for performing or collaborating In vivo PK/PD studies done in preclinical models including ex vivo assays (i.e. ELISA based PD read outs). Oversight and/or contribution to ADME work during drug development may be required. The in vivo PharmacologySenior Principal Scientist / Scientific Lead will report findings directly to both the Loxo scientific and executive leadership, and will be a key member of the discovery organization being responsible for maintaining the scientific quality and efficiency of the organization, as well as assist and guide the strategic direction of the company. The candidate is expected to be a dynamic and motivated scientist who can drive experiments and research activities independently, while collaborating extensively with the entire organization to execute various research programs.
Roles and Responsibilities of the Position:
Design, execute and oversee the execution of In vivo studies with pre-clinical discovery and translational biology teams
Interact and collaborate with various Discovery Technologies functional teams to develop and implement novel In vivo models
Prepare drug solutions and inoculations, multiple route drug administration, animal health monitoring, anesthesia, blood samplings, necropsies, xenografts, syngeneic mouse models, humanized mouse models
Culture tumor cells according to SOPs and contribute to the development of SOPs
Work collaboratively with the discovery and clinical teams to support retrospective and exploratory efforts for clinical programs
Perform cardiac, retro-orbital bleeds, and tumor injections
Perform tumor measurements using calipers
Harvest tumor and tissue samples from treated animals to help establish PK/PD and toxicity measurements
Process blood and tissue samples for monitoring PD markets, hematological and tissue toxicities
Liaise with CROs and vendors to outsource activities, provide input to management team on vendor selection
Stay current on cutting edge technologies and work collaboratively with the In vivo team to validate and implement new In vivo model systems
Provide scientific expertise on practical implementation of various In vivo applications to support projects across the entire Loxo organization
Work with the entire In vivo team to ensure all instrumentation is properly maintained and calibrated
Provide scientific expertise when determining organizations to strategically partner with
Proper documentation and archiving of data and analyses
Work interactively with project teams and discovery teams to plan and execute experiments as well as be involved in data interpretation and preparation of study reports
Work interactively with project teams as an In vivo Pharmacology expert to ensure appropriate applications and priorities are considered
Additional roles and responsibilities:
Communicate results via written and oral presentations at project team meetings, be involved in the coordination and preparation of presentations
Discuss results with technical as well as non-technical personnel
Support archiving as well as curating data in internal databases
Extensive cross functional communication and collaboration with internal and external parties
Interrogate experimental conduct of third parties/vendors
Required Qualifications:
PhD in biological sciences with 3-5 years of experience required
Extensive expertise in: In vivo Pharmacology, cell line xenograft establishment, humanized mouse model systems, imaging, standard flow cytometry experiments, bioanalytical functions, small animal handling, carrying out preclinical rodent oncology modeling
Additional Preferences:
Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships
Experience in drug discovery with regulator reporting
Proven success working in cross-functional teams in dynamic organizations
Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
Demonstrated business acumen
Demonstrated excellence in making key strategic decisions in support of broader business goals
Excellent written and verbal communication skills
Flexibility to adjust priorities over time to meet organizational and scientific goals
Ability to work independently and as an integral part of a larger collaborative team
Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
Excellent interpersonal, written, and verbal communication skills
Knowledge and experience documenting and processing In vivo studies
Physical Demands/ Travel: TBD <5%
The physical demands of this job are consistent with working in a lab.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
Lilly currently anticipates that the base salary for this position could range from between $111,000 to $178,200 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Of course, the compensation described above is subject to change and could be higher or lower than the range described above. Further, Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.
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