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SalaryPOSITION SUMMARY:
The highly motivated Scientist will work within the Omics group to develop and apply state-of-the-art proteomics technology to address compelling questions in biology, chemistry and clinical medicine. This role will join a team responsible for biomarker discovery/validation in multiple disease areas, including neurodegenerative diseases and cancer.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Spearhead technical analysis of post-translational modifications (phosphorylation, acetylation, ubiquitinylation, etc.) Contribute to the assessment of chemoproteomic analysis for MOA of specific compounds under investigation.
- Identify the mechanism of action of drugs and drug-like molecules, developing and optimizing novel, broadly enabling proteomic technologies including targeted, quantitative MS assay development for proteins and modifications.
- Collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis.
- Mentor research associates.
- Other duties as assigned
REQUIREMENTS:
- Requires a Ph.D. degree in Biology, Biochemistry, Chemistry or Analytical Sciences with relevant postdoctoral experience and 3-5 years' experience with nanoLC-MSMS analysis using HR/HA mass spectrometry instruments.
- A strong background in state-of-the-art proteomics, more specifically post-translational modification analysis; some experience in cell biology, signaling and/or systems biology.
- Familiarity with high-throughput quantitative methodologies such as TMT® and Label-free approaches.
- Ability to apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess the selectivity of compounds.
- Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues.
- Demonstrated ability to analyze, interpret and present data in a clear fashion.
- Solid scientific training/productivity as identified through high-impact publications demonstrating creative thinking as well as innovative technical approaches.
- Experience with Thermo instrumentation platforms is a plus.
