Address
Form of workAbout the Department
Dicerna, a Novo Nordisk company, is focused on driving innovation in RNAi (ribonucleic acid interference) to selectively target and silence genes that cause or contribute to disease. Our proprietary GalXC™ and GalXC-Plus™ RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. Established as a Transformational Research Unit (TRU) following Novo Nordisk’s acquisition of Dicerna Pharmaceuticals, Inc. in December 2021, the Dicerna TRU is a unique new organization within Novo Nordisk that brings together the best of both worlds – the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. With approximately 200 researchers, scientists, drug developers and operational staff, we are a team of inventive and entrepreneurial thinkers pushing the boundaries of science to create and drive new RNAi-based therapies for both rare and more prevalent diseases from the bench to the clinic. Together, we are driving change. Are you ready to make a difference?
The Position
We are seeking an experienced bioanalytical scientist specializing in LC-MS based pharmacokinetics (PK), biodistribution analysis, metabolite identification and/or biomarker assay development to join the Bioanalytical Chemistry team. You will help to further develop and implement our bioanalytical and biomarker strategies to assist in the optimization of our GalXC™ and GalXC-Plus™ platforms. It is highly desired that you will have experience in applying diverse mass spectrometric workflows such as high-resolution and triple quadrupole mass spectrometry to characterize and quantify drug and its metabolites via in vitro and in vivo assays. Experience in the bioanalysis and quantitation of pharmaceuticals in biological matrices and familiarity with oligonucleotide bioanalysis would be a major advantage. “
Relationships
This position reports to the Director, Bioanalytical Chemistry.
Essential Functions
- Develop advanced and robust LC-MS analytical methods for the bioanalysis of different molecular formats such as small molecules, oligonucleotides, peptides, and/or proteins.
- Conduct metabolic profiling and stability assessment of oligonucleotides in cellular, sub-cellular and biological tissue extracts
- Review and interpret complex LC-MS-based data sets and articulate findings to project teams
- Maintain/document records of all experiments, including QC review data, experimental results, and reports as appropriate into electronic laboratory notebooks
- Able to review and translate complex LC-MS based metabolism data sets and articulate findings to project teams
- Contribute to the team’s knowledge through updating scientific literature and discussions
- Maintain and troubleshoot lab instruments such as biological sample extraction systems, HPLC, and LC-MS
Physical Requirements
0-10% overnight travel required.
Qualifications
- Required:
- PhD or Master’s degree in pharmaceutical sciences, analytical chemistry, chemistry, biochemistry or related disciplines with relevant experience from industry or academia required.
- Strong background in LC-MS, ADME science and/or bioanalytical assays required.
- In-depth knowledge of chromatography and biological sample preparation techniques. Knowledge of liquid handlers and automated workflow is a plus
- Experience with bioanalysis of different molecular formats such as small molecules, peptides, oligonucleotides and/or proteins is a plus.
- Self-motivated with a proactive mindset
- Excellent communication skills (both written and oral)
- Ability to thrive in a multi-disciplinary and fast-paced research environment
We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.
At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.
If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.
