Address
Form of workThe Scientist - Development assists in the manufacturing processes and process development activities in collaboration with staff. This position requires a strong scientific background in the conduct of research in the Biological Sciences and requires an individual with proven technical skills and practical knowledge in biologics production and scale-up in one or more of the following areas: gene therapy vectors, Monoclonal Antibodies, small molecules (i.e. peptides, cytokines), recombinant proteins, or bacterial/viral/DNA vaccines. The position is responsible for the proper conduct of specific projects, collection and analysis of data.
The Therapeutics Production and Quality department within our Good Manufacturing Practices (GMP) facility is looking for a Scientist - Development to design and implement process development experiments with minimal supervision including both upstream and downstream unit operations. In this role you will perform small scale cell culture experiments, set up and run bioreactors for culture of mammalian or bacterial cells, and optimize purification methods using various chromatography techniques. Experience in mammalian and bacterial cell culture, bioreactors, protein purification, plasmid DNA purification, tangential flow filtration and various other filtration techniques is preferred. You will generate purified plasmid DNA and gene therapy vectors including Lentiviral.
Job Responsibilities:
- Coordinate multiple aspects of projects/processes within area (GMP/ECTL) with guidance, and execute processes (e.g., tech transfer & scale-up runs, HPLC/biologic assays, manufacturing of cellular therapeutics) utilizing appropriate techniques, equipment, and methods.
- Provide inputs regarding revisions to SOPs and/or process flows within area.
- Support development, documentation, and reporting of relevant experimental data (e.g., production batch records, HPLC reports, summary reports for manufacturing campaigns).
- Monitor and document compliance with quality and regulatory requirements; and address deviations.
- Support monitoring and stocking of supplies, and calibration, maintenance, troubleshooting, and purchase of equipment within area.
- Instruct other staff in basic techniques, procedures, and systems within area (e.g., operations of cGMP equipment and control software).
- Perform other duties as assigned to meet the goals and objectives of the department and institution.
- Maintains regular and predictable attendance.
Minimum Education and/or Training:
- Bachelor's degree required.
- Master's OR PhD preferred.
Minimum Experience:
- Minimum Requirement: Bachelor's degree with 7+ years experience in relevant scientific area (e.g., GMP: chemistry, biology, chemical engineering, analytical chemistry, biotechnology; ECTL: cellular biology, molecular biology, immunology, biochemistry).
- Experience exception: 5+ years of experience in relevant area with Master's
- Experience exception: 3+ years of experience in relevant area with PhD
- Prior experience in relevant area to own domain (e.g., upstream/downstream cGMP experience, process development, HPLC/biological assays) strongly preferred.
- Experience in lab and scientific project coordination, maintenance, and other research support activities preferred.
St Jude Employees receive:
- Excellent healthcare plans with zero to low health premium costs
- Onsite health clinic, pharmacy, and exercise facilities
- Paid parental leave and adoption assistance
- Immigration Services
- Tuition Reimbursement
St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.
Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.
Other InformationSt. Jude is an Equal Opportunity Employer
No Search FirmsSt. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
