Research Fellow, Pgy0(Zebardast)

POSITION SUMMARY:

We are seeking a highly qualified and motivated postdoctoral fellow to join our collaborative teams in the Ocular Genomics Institute and the Department of Ophthalmology at Massachusetts Eye and Ear (MEE), Harvard Medical School, to work on innovative projects that combine human genetics and functional genomics to uncover novel causal mechanisms for common eye diseases, including glaucoma and inherited retinal degeneration

The successful candidate should have a PhD in bioinformatics, computational biology, biostatistics, computer science, machine learning or a related quantitative field, and will be interested to apply and develop computational and statistical methods for analyzing sequencing data, large-scale genotype-phenotype association studies, and functional genomics data. The ideal candidate will have strong programming skills, a solid statistical understanding, and experience with large-scale data analysis, ideally with genomic or other omic data, and will be excited to contribute to advancing the scientific discovery and medicine of eye disease.

The candidate will work with Drs Zebardast and Rossin, that are part of a vibrant research community of computational biologists, experimentalists and clinician scientists in the Ocular Genomics Institute at MEE, an international leader for treatment and research in Ophthalmology and Otolaryngology. The labs are affiliated with the Medical and Population Genetics community at the Broad Institute of Harvard and MIT. Being a member of our group will provide the opportunity to contribute to impactful projects and large collaborative efforts in the field of genomics and human disease. To learn more about our lab research directions please visit: https://oculargenomics.meei.harvard.edu/team/.

If interested, please send your CV, a cover letter describing your previous research experience and future research interests, and contact information for 3 references, to Dr. Nazlee Zebardasrt : Nazlee_Zebardast [at] meei.harvard.edu, and Dr. Lizzy Rossin: Elizabeth_Rossin [at] meei.harvard.edu.

CHARACTERISTIC DUTIES:

• Perform preprocessing and quality control of genotype array, whole exome and whole genome sequencing data, using existing and custom-built tools on a local HPC cluster and cloud-based environment.
• Perform association testing of common and rare variants in whole exome and whole genome sequencing data from cohorts of early and late-onset glaucoma and controls, and from Biobank studies as well as longitudinal cohort studies

• Build polygenic risk scores in large genotype-phenotype studies of glaucoma and test for association with various clinical features to help translate genetic discoveries into personalized approaches for disease diagnosis and treatment.
• Perform structure-based network analysis on mutations in rare inherited retinal degeneration genes and apply to patient sequencing data to identify and distinguish causal variants from neutral ones using a pre-existing pipeline built in Python and R.
• Help optimize the code for the structure-based network analysis pipeline using benchmark data
• Organize all scripts in a publicly available repository (e.g., github) with clear documentation.
• Critically review, analyze, and communicate results to our team and collaborators.
• Candidate will work both on independent and collaborative projects, and will summarize work for publications.

Requires a Masters and/or Ph.D in their field of specialty. 1 to 5 years experience preferred.

EDUCATION AND EXPERIENCE:

• Ph.D. in bioinformatics, computational biology, computer science, machine learning, (bio)statistics, mathematics, or a related quantitative discipline required.
• Strong programming skills and in-depth experience with several programming languages required, e.g. Python, R, C ; Experience with Cloud Computing a plus.
• Experience with Unix/Linux environments, including shell scripting, is required.
• Research experience with large-scale data analysis, such as next-generation sequencing, algorithm development and statistics required.
• Background in statistical genetics, computational genomics, or machine learning is a plus.
• Motivation to contribute to genomic research of eye disease is essential.
• Demonstrate critical thinking, rigorous work, and ability to meet deadlines.
• Strong personal skills, and excellent organization and verbal and written communication skills.
• Ability to work effectively both independently and collaboratively in a fast-paced, academic environment and evolving field.

WORKING CONDITIONS:

The Zebardast and Rossin labs are located in the main hospital building of Mass Eye and Ear, 243 Charles Street, in a research and office workspace that is part of MEE's Ocular Genomics Institute. The postdoctoral fellow will work in an office space adjacent to other computational biologists, biostatisticians, and students and in the Bioinformatics Center of the Ocular Genomics Institute, and will be part of a larger multidisciplinary research environment, which includes geneticists, clinical scientists, and experimental biologists. There is convenient access to MEE cafeteria on the 7th floor and, more importantly, abundant opportunities to interact with other MEE research groups and the Medical and Population Genetics community at the Broad Institute. The position will be hybrid with both remote and in-person components.

PHYSICAL REQUIREMENTS:

None.