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SalaryAbout Us
Our mission is to develop transformational genetic medicines utilizing novel delivery technologies, with an emphasis on diseases with significant unmet medical need. Our team is advancing multiple innovative approaches to deliver a variety of therapeutic payloads, focusing initially on gene editing in therapeutically relevant cells and tissues. Our world class scientific founders include Professor David Liu (HHMI, Broad and Harvard) and Professor Keith Joung (Arena BioWorks, formerly MGH), and we are funded with a significant capital investment by leading life science venture capital firms including Newpath Partners, Atlas Venture, F-Prime Capital, and 5AM Ventures. We believe that our technology has the potential to positively impact patients suffering from severe genetic diseases, and we are committed to building an excellent, science-driven and diverse team that is passionate about making a difference. Nvelop Therapeutics is based in Cambridge, MA.
We are seeking a motivated and growth-oriented Process Engineer to join our Process Development team. This is a lab-based position, and the individual will assist in the scale-up of our cell-based manufacturing process to produce non-viral drug delivery vehicles. The candidate will design and execute experiments to optimize the bioreactor operation parameters leading to comparable product quality as the early versions of the process. The individual will communicate experimental findings on a regular basis across a matrixed team of scientists and engineers.
The ideal candidate will have the drive to execute, have experimental rigor and scientific curiosity for early-stage Process Development activities. We are a small and growing company, so the flexibility to work on both Process Development and scale-up activities, ability to work in a fast-paced environment and adapt to evolving priorities is a must!
Job Responsibilities
- Assist in the evaluation of various bioreactor modalities to determine a lead bioreactor-type for particle production
- Develop and execute a protocol for scale-up of particle production from a shake flask to 50L scale
- Participate in the planning, execution, and data analysis of statistical design of experiments for early Process Development activities in non-bioreactor modalities.
- Work closely with the team to identify a feed and harvest strategy for maximizing product titer and minimizing impurities
- Identify key process parameters for bioreactor operation that could affect product quality and work with the upstream team to mitigate them
- Assist in technology transfer across different groups within the company
Skills and Qualifications
- Degree in chemistry, biology, engineering, or a related field; Bachelor’s or Master’s degree with 3-6 years of relevant industry experience
- Hands-on experience with single-use stir-tank bioreactors (SUB), and/or WAVE up to 50L scale
- Hands-on experience with aseptic sampling, metabolite analysis, pH and DO2 measurements
- Experience with viral or non-viral delivery platforms and/or gene therapy is desirable but not required
- Experience working with CDMOs and cGMP guidelines is desirable but not required
- Strong problem-solving, organization, and communication skills. Ability to work collaboratively and adapt to a fast-paced environment
Additional Requirements:
Full time in-person work is necessary for our laboratory-based positions. We work in facilities that require that all individuals working on-site are vaccinated for COVID-19. Position Title and Salary will be commensurate with Experience
We recognize the value of diversity in our workforce and are committed to building a welcoming and supportive working environment. We consider all qualified applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment in the United States will be considered without regard to citizenship/alienage.
We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.
