Modeling And Simulations Scientist

The Position
THE POSITION
The Translational & Systems Pharmacology Group within the PKPD Department at Genentech, Inc. is seeking a PKPD/QSP Modeling & Simulation Scientist who is driven to enhance drug development through quantitative Modeling and simulation of PKPD and biological systems. Our group supports projects in various stages of research and development across a range of therapeutic areas and molecule types/formats. We comprise scientists with PhDs in computational disciplines with expertise in mechanistic biological Modeling and simulation, data-driven modeling, bioinformatics and systems biology, computational algorithm and tool development, and translating complex biology into quantitative models. We work closely with collaborators across all disciplines in therapeutic areas such as oncology and cancer immunotherapy, immune and inflammatory disorders, ocular disease, neurological disorders, and more. Efficient communication and collaboration with biological and clinical collaborators are critical skills. The group has a significant external presence, with a growing list of publications in highly regarded journals in the field, numerous oral presentations, academic seminars, and workshop leadership. Our members are leaders of various interest groups, conference programming committees, and working groups in the field of pharmaceutical Modeling and simulation. In addition to our application of PKPD and systems modeling approaches in support of drug development, we are also committed to the development of new technical approaches, algorithms, and tools to advance the field.
Responsibilities

• Develop and apply mechanistic PKPD and systems pharmacology models in various therapeutic areas including oncology, immune & inflammatory disease, and other disease areas to support our drug development pipeline.
• Independently strategize, plan, execute, and report QSP and PKPD modeling activities, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences.
• Work in close partnership with other scientists in Modeling and Simulation, Clinical Pharmacology, Clinical Science, Informatics, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions.
• Contribute to best practices on application of QSP and mechanistic PKPD in drug development
• Present results at cross-functional teams, department meetings, review committees, and conferences.
• Adapt and thrive in an interactive, team-oriented culture.

Qualifications

• Ph.D in: chemical, biomedical, or other relevant engineering fields, pharmaceutical sciences, or a related discipline.
• Typical post-PhD experience requirements are roughly: Senior Scientist, ~0-3 years; Principal Scientist, ~3-7 years; Senior Principal Scientist, 7+ years
• Proficiency with PKPD and biological systems modeling approaches such as differential equations, logic, stochastic, agent-based, and/or other advanced mechanistic modeling approaches is essential as is proficiency with appropriate programming language and software (e.g., MATLAB/Simbiology, R, C)
• Excellent communication and interpersonal skills and the ability to work independently and effectively on cross-functional teams.
• Strong leadership skills and the ability to influence project team collaborators.
• Strong track record of external scientific presentation and publication, commensurate with hiring level

The expected salary range for this position based on the primary location of California is $183,100 - $340,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Who we are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.
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