Manufacturing Supervisor, Pipeline Product Support (PPS)

Your Impact

Our dynamic, supportive, and highly collaborative PPS team is looking for someone who has a strong work ethic and quality driven mindset. In this role, you will be helping to produce critical raw materials that are foundational to all stages of Poseida’s pipeline development; from discovery, through preclinical research, to early phase clinical trial manufacturing. This individual will possess strong communication skills to effectively work with various departments to ensure material demands are met, identify and test viable scale up processes, and further align with future GMP objectives. Your passion and expertise will directly contribute to Poseida’s mission of developing and delivering therapeutics that have the capacity to cure.

Position Summary

The Manufacturing Supervisor works as part of the PPS team to deliver high quality nucleic acids in support Poseida’s internal manufacturing goals, R&D objectives, and successful external collaborations. The Manufacturing Supervisor oversees the daily operations including production and operator scheduling, inventory management, document review, and participates in manufacturing productions on an as needed basis. This position is the direct supervisor for the manufacturing staff and understands the requirements needed to meet quality and regulatory compliance in a GMP environment.

Responsibilities

These may include but are not limited to:

• Perform and support critical GMP and highly documented aseptic operations in ISO 5 and ISO 7 production environments, following paper-based and/or electronic batch records, standard operating procedures (SOPs), policies, and work instructions to ensure safe and compliant operations
• Work as part of a team to execute operations in close collaboration with Supply Chain, Pilot Plant Manufacturing, Facilities, and Quality departments
• Plan the production schedule based on internal and external manufacturing needs, R&D forecasted demand, and material requisitions received from Poseida’s strategic collaborators
• Identify and initiate process improvement experiments and scale-up activities
• Escalate processing and equipment issues, as needed. Participate in deviation writing, root cause investigations, and CAPAs when necessary
• Maintain sufficient inventory of supplies and raw materials to support scheduled production campaigns, and negotiate favorable pricing from vendors
• Author batch records for new production processes and initiate periodic revisions to implement process improvements and documentation updates.
• Assist in SOP and STM generation
• Support regulatory filings for various clinical programs
• Conduct training activities
• Ensure a right-the-first-time philosophy of all process steps and documentation, as well as help drive the safety-first culture at Poseida

Requirements, Knowledge, Skills and Abilities

• Bachelor’s degree in life sciences or biological/chemical engineering and/or 2+ years of work experience (an equivalent combination of education and experience may be considered)
• Prior biotechnology GMP manufacturing experience is preferred
• High level technical understanding of plasmid amplification and purification, as well as mRNA in-vitro transcription and purification (both upstream and downstream)
• Excellent aseptic technique
• Self-motivated, positive, and detail oriented with strong problem-solving and critical thinking skills
• Demonstrated ability to work effectively in a dynamic, cross-functional and fast-paced team environment
• Proficient in data analysis and data management (e.g., inventory records, manufacturing data)
• Strong oral and written communication skills. Proficiency with MS-Office suite of software
• Bonus: Bioreactor, Chromatography, Plasmid cloning experience
• Some overtime work will be required
• Subject to extended periods of standing and/or sitting continuously and repetitive arm/wrist motions
• Must be able to work in controlled environments requiring special gowning. Will be required to follow gowning requirements and wear protective clothing over the head, face, hands, feet, and body
• Must be physically capable of lifting 30 pounds

Manufacturing Supervisor, Pipeline Product Support (PPS) Pay Rate: $44.71/hour to $55.77/hour

The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.

Who We Are and What We Do

Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients’ lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.

At Poseida we put people first. Our team is passionate about improving patients’ lives through innovation. See what our team has to say about our culture:

“My favorite part about Poseida is all the people that I get to work with.Everyone is so passionate about what we’re doing here and there’s so much camaraderie.It feels like one big enthusiastic family.”

“My favorite part about working at Poseida is the amazing culture and working environment.Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude.”

As we advance our compelling pipeline, there are endless opportunities for impact and growth. We encourage you to apply today!

Recruitment Fraud Alert

Alert: Beware of Employment Scams

Poseida Therapeutics, Inc. has received reports of employment-related scams. These scams have appeared in forms of false job advertisements and/or unsolicited contacts via communication/chat platforms, phone, email or text from individual(s) claiming to be or represent Poseida’s Human Resources team. Be advised that Poseida Therapeutics does not extend unsolicited employment offers. Furthermore, Poseida Therapeutics does not request payment information or charge prospective employees with any fees during the recruitment process.

If you would like to pursue employment opportunities with Poseida Therapeutics, Inc., please visit our official careers website https://poseida.com/careers-culture/ or official Poseida Therapeutics LinkedIn page. Job postings that do not link directly to our careers website or official Poseida LinkedIn page are not legitimate and might be fraudulent. You may report fraudulent job advertisements or contacts via our Contact Us page at https://poseida.com/contact-us/ and select the subject “Careers.” If you have been defrauded or suspect identity theft as a result of an employment scam, please contact your local law enforcement agency for guidance.