Institute Research Investigator Adme/Pk

MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
The Institute Research Investigator in the ADME/PK Group will contribute to the advancement of IACS small molecule drug discovery projects by leading ADME and biotransformation studies. The scientist will enable advancement of projects through both leadership and experimental activities. The position requires a highly self-motivated individual, with outstanding organizational and communication skills. The ability to work well under pressure and drive towards individual and team objectives that impact critical timelines is expected. A collaborative attitude is essential for the position.
They will have good communication skills and will regular liaise with other members of the cross-functional project team. This individual will be a key contributor in the identification and optimization of the next generation of cancer therapeutics.
JOB SPECIFIC COMPETENCIES
* Conduct metabolite identification of small molecule drug candidates using LC-HRMS.
* Perform and lead in vitro ADME assays on drug discovery programs, such as liver microsomal and hepatocytic stability assays, plasma protein binding assay, and MDCK cell permeability assay etc.
* Write validation protocols and reports; maintain accurate research records and laboratory notes; Be able to critically analyze and verify data prior to data release; Trouble shoot assay issues.
* Serve as the ADME/PK representative on project teams; Interact effectively with these cross-functional teams towards the optimization of drug candidates with optimal ADME-PK properties and serve as a point of contact on the programs.
* Independently propose innovative solutions to research projects and contribute to project goals through laboratory experiments.
* Apply and develop cutting edge basic science tools and methodologies to develop complex strategies and enable advancement of Institute projects through leadership and experimental activities.
* Supervise and train research associate scientists.
Working Conditions
Office environment

This position requires:
Working in Office Environment
____No
__X_ Yes
Working in Patient Care Unit (e.g. Nursing unit; outpatient clinic)
_X_ No
____ Yes
Exposure to human/animal blood, body fluids, or tissues
__X__No
__ _ Yes
Exposure to harmful chemicals
__X__No
___ Yes
Exposure to radiation
_X_ No
____ Yes
Physical Demands
Indicate the time required to do each of the following physical demands:
Time Spent
Never
0%
Occasionally
1-33%
Frequently
34-66%
Continuously
67-100%
Standing
X
Walking
X
Sitting
X
Reaching
X
Lifting/Carrying
Up to 10 lbs
X
10lbs to 50 lbs
X
More than 50 lbs
X
Pushing/Pulling
Up to 10 lbs
X
10lbs to 50 lbs
X
More than 50 lbs
X
Use computer/keyboard
X
EDUCATION:
Required: Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: PhD in Medicinal Chemistry or relevant field.
EXPERIENCE:
Required: Six years experience of relevant research experience in laboratory With Master's degree, four years of required experience. With a PhD in a natural science or Medical degree, no experience required.
Preferred:
PhD degree in Medicinal Chemistry or relevant field with hands-on experience in high resolution or triple quadrupole mass spectrometers. Previous experience with in vitro ADME assays or metabolite identification is preferred but not required. Medicinal chemists considering career changes are encouraged to apply.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Additional Information

• Requisition ID: 165794
• Employment Status: Full-Time
• Employee Status: Regular
• Work Week: Days
• Minimum Salary: US Dollar (USD) 101,325
• Midpoint Salary: US Dollar (USD) 127,100
• Maximum Salary : US Dollar (USD) 152,000
• FLSA: exempt and not eligible for overtime pay
• Fund Type: Soft
• Work Location: Onsite
• Pivotal Position: Yes
• Referral Bonus Available?: Yes
• Relocation Assistance Available?: Yes
• Science Jobs: Yes

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