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Form of workJob Description
Reporting into a lead within the Process Sciences team, we are hiring an Analytical DevelopmentAssociate Scientist within the Process Sciences Organization in Technical Operations at CARGO Therapeutics. The candidate will contribute to the development of flow‑based, potency, and functional assays for lot release and extended characterization of CARGO’s CAR T-cell therapy products. The ideal candidate will have a background in cell-based assays and flow cytometry-based assays. The successful candidate will work closely with the Process Sciences team and the broader CMC team. The individual will also collaborate cross-functionally to ensure timely development and manufacture, and release of drug products as well as support regulatory submissions.
The position is onsite, lab-facing based in our San Mateo office.
WHAT YOU’LL DO AT CARGO THERAPEUTICS
Key responsibilities of the Associate Scientist are summarized below; these will evolve over time as the portfolio matures:
- Support planning and execution of experiments and associated analysis and reporting
- Develop and optimize multicolor, flow cytometry-based assays for CARGO’s T-cell therapy products
- Provide analytical support for technical development studies performed both internally and externally
- Participate in extended characterization of CAR T-cell products to support Clinical programs
- Support method transfer to partners at external Contract Manufacturing Organization including compilation of documentation (protocols, test methods, reports)
- Participate in laboratory set up and equipment procurement, and establish internal assay development practices
- Author relevant documentation (protocols, technical development, qualification reports)
- Organize, communicate, and present data to key stakeholders, senior management, and external partners
- Interface and work collaboratively with internal stakeholders and CDMO and testing lab partners
THE RIGHT STUFF: Required Experience & Qualifications
- Bachelor's or Master’s degree in a relevant scientific area such as biotechnology, bioprocess, molecular biology, immunology, biochemistry required
- 2-4+ years of relevant experience in T-cell biology and/or immunotherapy
- 2-4 years of relevant experience in biopharmaceutical setting, including successful performance track record in establishing and applying analytical assays for cell therapy products
- Experience in multi-color flow cytometry analyses, including panel design and data analysis essential
- Expertise in mammalian cell culture techniques preferred with experience in flow-based T-cell functional assays including proliferation assessment, cytotoxicity, cytokine/chemokine
- Ability to work in a highly adaptive environment and learn new skills for changing priorities
- Ability to coordinate tasks across multiple projects to meet deadlines
- Experience with Electronic Lab Notebooks
- Flexible and creative; able to think outside the box
- Must have excellent interpersonal, organizational, written, and verbal communication skills, and the ability to work collaboratively in a team environment
- Proficiency in Office, Design of Experiments, JMP, Prism, and other productivity and data analysis tools
PAY RANGE
The combined pay range for this role is $97,000 - $134,000. Title and salary will be based on our assessment of skills and experience relevant to our needs for the role.
ABOUT CARGO THERAPEUTICS
CARGO Therapeutics, Inc. is a clinical-stage biotechnology company positioned to advance next generation, potentially curative cell therapies for cancer patients. CARGO’s programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved cell therapies, including limited durability of effect, safety concerns and unreliable supply. CARGO is currently evaluating its lead program, CRG-022, an autologous CD22 chimeric antigen receptor (CAR) T-cell therapy candidate, in a potentially pivotal Phase 2 clinical trial in patients with large B-cell lymphoma (LBCL) whose disease relapsed or was refractory (R/R) to CD19 CAR T-cell therapy. CARGO also plans to evaluate CRG-022 in patients at earlier stages of disease, including LBCL and other hematologic malignancies. Beyond its lead program, CARGO is leveraging its proprietary cell engineering platform technologies to develop a pipeline of programs that incorporate multiple transgene therapeutic “cargo” designed to enhance CAR T-cell persistence and trafficking to tumor lesions, as well as to help safeguard against tumor resistance and T-cell exhaustion. CARGO’s founders are pioneers and world-class experts in CAR T-cell therapy, and its team has significant experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at https://cargo-tx.com/.
Join us to help make a difference!
EEO & EMPLOYMENT ELIGIBILITY
CARGO Therapeutics, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status. CARGO Therapeutics, Inc. also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification required of applicable law.
CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at CARGO Therapeutics, and it applies regardless of whether the position is located at a CARGO Therapeutics site or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.
