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Form of workRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
Playing a critical role as a lead statistician for clinical program(s) and the subject matter expert (SME) in Biostatistics within Quantitative Sciences function, this position is to serve as a program-level lead statistician and provide statistical leadership and support for clinical development strategy and programs through product life cycle.
Lead strategic, statistical thinking and contributions to clinical development plans.
Represent Biostatistics function on cross-function teams at program level and serve as a lead statistician for oncology studies.
Collaborate with various functions on study design and planning, protocol development, statistical analysis plan and analysis specifications.
Provide statistical support for study protocol development, analysis plan and specification through direct involvement and/or providing guidance to junior staff.
Plan and prepare independent data monitoring committee (DMC), coordinate with independent statistical data analysis center for DMC and study team for periodic DMC reviews.
Collaborate with data management and clinical operations over the course of clinical studies to provide statistical input to study conducts and database development as well as data collection and cleaning activities.
Collaborate with statistical programming to ensure that appropriate programs and documentations are being developed for datasets development and outputs generation, and ensure the statistical analyses specified in scientific protocols and/or analysis plans are conducted appropriately.
Provide statistical input and leadership to the development of global health authority documents, regulatory interaction, and response to health authority submissions.
Provide statistical support for clinical publications, assist in data interpretation to ensure consistency and accuracy in data presentation.
Drive and lead department initiatives, best practices, and guidelines.
Keep abreast of new developments in statistics, drug development, and regulatory guidance and share knowledge with functional and cross-functional team members.
Education, Experience and Skills Requirement:
Ph.D. or M.S. in Statistics/Biostatistics, minimum 6 years (for Ph.D.) and 8 years (for M.S.) of experience in biotech/pharma industry as a statistician. Level will be determined based on the relevance of experience.
Hands-on experience in design and analysis of phase 3 oncology trials is strongly desirable.
Solid knowledge in ICH and other regulatory requirements related to biostatistical activities and clinical trials.
Excellent verbal and written communication skills are required.
Good interpersonal and project management skills are essential.
Proficiency in SAS and/or R.
Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company's offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.
The expected salary range for this role is $200,000 to $240,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.
