Company Profile:
Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte's lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company's system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte's pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit www.vaxcyte.com.
Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company's balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte's Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children. VAX-24 is being investigated for the prevention of IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte's PCV franchise, consisting of VAX-24 and VAX-31, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease. We believe that our PCVs could receive regulatory approval based on successful completion of clinical studies utilizing well-defined surrogate immune endpoints, consistent with how other PCVs have obtained regulatory approval in the past, rather than requiring clinical field efficacy studies.
Summary:
Vaxcyte is looking for an accomplished, driven, energetic and pragmatic leader with extensive Analytical Development experience, to join Vaxcyte's Analytical Development & QC organization as Associate Director (AD) of Analytical Development for Raw Material.
This pivotal role will spearhead analytical method development for Raw Materials, serving as the analytical technical leader for all analytical activities related to Raw Materials within the company and a complex network of approximately 10 Contract Development and Manufacturing Organizations (CDMOs). These Raw Materials encompass a diverse range, including small molecules, enzymes, complex cell extracts, plasmid DNAs, and more-a list that continues to expand. Consequently, there is a broad scope of analytical technologies used, and expertise with analytical methods used in assays for these Raw Materials or the ability to quickly adapt to them is crucial.
This role is primarily outward-facing, where you will play a critical role in method development, transfer, and validation. The Associate Director of AD for the Raw Material will review all raw material-related analytical and QC documents to ensure their accuracy and quality. The role will also be responsible for establishing raw material analytical control systems and ensuring the timely completion of critical deliverables. Your leadership will be instrumental in resolving technical, compliance and cross-functional issues and determining priorities for Project Management (PM) and other ADQC project team members, ultimately contributing to the success of our projects.
This role offers a unique opportunity to lead and shape company's Raw Materials program, both internally and within our network of CDMOs. You will have a significant impact on the technical quality of our projects and contribute to our company's continued success.
Reports to: Vice President, Analytical Development & Quality Control
Location: San Carlos, CA
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $182,000 - $188,000
Send resumes to:
careers@vaxcyte.com
Vaxcyte, Inc.
825 Industrial Road, Suite 300
San Carlos, CA 94070
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.