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Form of workJOB SUMMARY:
Responsible for designing and conducting research studies to support our drug discovery programs, including target validation, structure-activity relationship assessment, biomarker discovery, and mechanism of action studies. In addition, evaluates the effects of novel compounds in cancer models (in vitro & in vivo). Hands on, laboratory focused role.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Maintain cancer cell lines and establish stable/drug resistant cell lines.
- Perform semi high-throughput assays and prepare/maintain necessary assay reagents.
- Participate in target validation.
- Develop and conduct various cell-based assays to characterize potency of drug candidates.
- Develop and validate new assays & technologies.
- Develop other molecular biology-based assays using techniques such as cloning, DNA/RNA/protein extraction and RT-PCR.
- Analyze, interpret, and generate data reports in a timely manner.
- Troubleshoot complex assays.
- Other projects and assignments as required.
EDUCATION/KNOWLEDGE/SKILLS/ABILITIES REQUIRED:
- BS/MS with 5-8 years of experience (pharmaceutical/biotech industry)
- Knowledge of cancer biology, signal transduction pathways and transcription regulation.
- Hands-on experience with cancer cell culture and cell-based assays with a variety of readout technologies in low, medium, and high throughput. Experience in spheroid /organoid culture is desirable.
- Experience with cell genetic manipulation techniques, such as siRNA, shRNA, and CRISPR is desirable.
- Highly experienced in protein assay development such as western blot/JESS, flow cytometry, ELISA, AlphaLisa, and immunoprecipitation.
- Experienced in cellular viability assays, and molecular biology techniques, such as cloning and qPCR.
- In-depth experience of how to use basic software for data analysis (e.g., Prism, Microsoft Excel) and generating reports (PowerPoint).
- Ability to work independently, multi-task, and prioritize daily activities.
- High attention to detail.
- Demonstrates a high level of accuracy and effective oral and written communication skills.
- Flexibility within a rapidly changing environment.
- Excellent ability to work in a goal and team-oriented setting.
- Well-developed organizational skills.
