We are seeking a highly motivated Sr. Associate Scientist who will be responsible for providing in-depth characterization of therapeutic protein candidates to support developability assessments. We also participate in technology innovation efforts aimed to enhance our understanding of novel protein therapeutics using solution-state and computational approaches.
A typical day in the role might look like:
- We conduct biochemical and biophysical characterization experiments and analyzes data to elucidate quality attributes of therapeutic protein candidates providing support for develop-ability assessments and related method development efforts.
- We provide input on experimental design and suggests method adaptations to address needs of a program or attributes of novel protein therapeutics.
- Additional responsibilities will include method development of advanced technologies that evaluate the size/structural heterogeneity and/or thermodynamic and hydrodynamic interactions of novel protein therapeutics.
- May support computational efforts that help advance predictive modeling efforts for solution-state biophysical properties of therapeutic protein candidates.
- Documents experiments, results, and findings in electronic laboratory notebook; presents work at group and departmental meetings, drafts protocols, method development reports, regulatory submission sections, and peer-reviewed publications.
- Maintain instruments, troubleshoot instrumental/experimental problems, and order/maintain supplies.
This role may be for you if:
- Good laboratory practice skills such as preparing samples, buffers, documentation and maintaining cleanliness are critical.
- Experience with rheology and analytical ultracentrifugation are a plus.
- Must have strong initiative and drive to complete tasks as well as ability and desire to learn new technologies.
- Must be capable of working both independently and within a collaborative environment.
In order to be considered qualified for this role, you must have a minimum of a BS degree with 4+ years relevant experience. or a MS degree with 2+ years of relevant experience. A degree in Biochemistry, Chemical Engineering, or Biophysics. Experience in automated chromatography (FPLC, H/UPLC), differential scanning calorimetry/differential scanning fluorimetry, spectroscopy (UV-Vis, fluorescence, FTIR, Raman, and/or circular dichroism) and/or multi-angle/dynamic light scattering (MALS/DLS) of macromolecules is ideal.
Salary Range (annually)