Senior Scientist - Protein Engineering And Structural Biochemistry

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history 

As a Senior Scientist for the antibody discovery and Protein Engineering (ADPE) group, you'll work closely with scientists in both Research and Development to advance Alector programs forward. Working closely with the Protein Sciences group you will also help design and generate therapeutic reagents and biologics with favorable functional and developability profiles.

Responsibilities:

• Utilize proven knowledge in protein structural biology and Structural analysis tools to support protein designs and optimization workflow
• Contribute to the reagent designs for antibody discovery and engineering, and hypothesis-driven experimental designs to gain mechanistic insights
• Devise and carry out antibody and Protein Engineering campaign strategies including high-throughput cloning, phage display and/or yeast display approaches to identify desirable properties
• Apply computational tools and Protein Engineering expertise to design and execute antibody humanization, affinity and developability optimization
• Serve as program lead and subject-area expert to coordinate data management, data analysis and presentations, and contribute to decision making in a collaborative and timeline-driven manner
• Help train and mentor junior scientists

We'd love to hear from you if:

• Your academic background includes a PhD in protein biochemistry, molecular or structural biology with 5+ years, MS with 10+ years, BS with 20+ years of relevant therapeutic discovery experience
• You have a strong understanding of biologics therapeutic development and desired candidate profiles
• You have deep knowledge of protein structural biology, protein purification, biochemistry, and structure/function relationships
• You are an expert in molecular biology and Protein Engineering techniques, including mutagenesis, molecular cloning, construct design, protein expression and purification, protein interaction characterization and DNA sequence analysis
• Your experience with phage and/or yeast display technology desired
• You have strong organizational skills in data management, timeline management
• You have excellent interpersonal, communication and presentation skills with the ability to coach and mentor more junior scientists, as well as positively influence project direction and strategy
• You take pride in being self-motivated and a creative problem solver, and value teamwork
• You have a point of view but are low ego

$143,000 - $155,000 a year

Base salary ranges will be determined by the candidate's level, qualifications, skill set, and experience.

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At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.  

Alector was named on Fortune's " Best Workplaces in Biopharma" top list for small and medium-sized companies for the third consecutive year! And we moved up from #16 to #11 in 2022 .  

Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! 

 

We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.  

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation.