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SalaryABOUT THE COMPANY
At Scout Bio (www.scoutbio.co) our mission is to create innovative medicines for companion animals that are more convenient, effective and safe than those currently available.
We're applying cutting-edge technologies from the world of human medicine to companion animal health (dogs and cats).
Our world-class team of human and animal health biotechnology veterans has an enviable track record of success, and now we're looking for a Senior Research Scientist to join our growing, international team.
Join us and play a key role in bringing Gene Therapy to veterinary medicine, to improve the quality of life for companion animals and their owners.
Our labs are based in the historic Curtis Building in beautiful Old City, Philadelphia.
ABOUT THE ROLE
This role within the Research Group of Scout Bio will be responsible for the pre-clinical evaluation and development of novel AAV Gene Therapy and protein-based therapeutics for companion animals. The successful applicant will have an expert understanding of AAV Gene Therapy.
Key duties
- Designing and constructing novel AAV-compatible transgenes, promoters and regulatory elements for in vitro analysis and proof-of-concept animal studies.
- Design, optimization, and execution of assays for the evaluation of transgene transduction, expression, potency and immunogenicity.
- Production and purification and quantification of small-scale vector preps.
- Evaluation and application of new platform technologies and product opportunities to expand our pre-clinical pipeline.
- Collaborating with cross-functional teams (including CMC, clinical and external collaborators) to ensure that information is shared, and studies are performed with scientific rigor.
- Writing and editing of preclinical study reports and preclinical sections in support of regulatory submissions.
- Effectively managing and mentoring junior-level staff and acting as a resource for providing scientific expertise.
This role will have a close working relationship with all other scientific staff at the company.
ABOUT YOU
You will have:
Essential skills knowledge and experience
- PhD with post-doctoral experience in one of the following disciplines: Virology, Molecular Biology, Biochemistry, Bioengineering or a related field.
- 3+ years of working experience in a preclinical research and development environment (adeno-associated viral vectors preferred).
- Expertise with molecular and cell biology techniques including ddPCR, viral transfections, immunogenicity assessments.
- Strong understanding of protein chemistry techniques as pertains to AAV vector purification and analysis.
- Demonstrated ability to work independently and cooperatively in a team-based environment.
- Ability to support multiple projects.
- Strong grasp of key scientific software programs (including Microsoft Office, graphing software and DNA/protein analysis tools).
- Strong organizational skills, analytical skills, and problem-solving skills.
- Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively in team meetings, and with external collaborators..
Job Type: Full-time
Salary: $90,000.00 - $120,000.00 per year
Benefits:
- 401(k)
- Dental insurance
- Employee assistance program
- Health insurance
- Paid time off
- Vision insurance
Schedule:
- Monday to Friday
Application Question(s):
- Can you reliably commute each day to our labs in the Curtis Building, Philadelphia, PA 19106? (This role is based full-time in our labs and cannot be done remotely).
- Do you have a PhD in one of the following disciplines: Virology, Molecular Biology, Biochemistry, Bioengineering or a related field?
- Do you have • 3+ years of working experience in a preclinical research and development environment (adeno-associated viral vectors preferred)?
- Do you have an expert understanding of AAV Gene Therapy?
- Do you have expertise with molecular and cell biology techniques including ddPCR, viral transfections, and immunogenicity assessments?
Work Location: In person
