Senior Principal Scientist

HOW MIGHT YOU DEFY IMAGINATION?

If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Senior Principal Scientist, Pharmacokinetics & Drug Metabolism

Live

What you will do

Lets do this. Lets change the world. The Pharmacokinetic & Drug Metabolism department (PKDM) is seeking a Senior Principal Scientist to characterize the pharmacokinetic and pharmacodynamic (PK/PD) properties of small molecules and emerging therapeutics. This position is based at the Amgen South San Francisco site with on site, hybrid, and/or remote work options for individuals located within the US.

The Senior Principal Scientist will be responsible for supporting small molecule drug discovery through to clinical development with the opportunity to expand support to other therapeutic modalities, such as antibody drug conjugates, targeted protein degraders, etc. The selected individual will lead teams within PKDM to systematically characterize the absorption, distribution, metabolism, excretion (ADME) as well as PK, and PD properties of molecules using in vitro and in vivo models. Also in this role, the Senior Principal Scientist will partner with cross-functional teams to design and identify promising molecules starting from discovery research through to IND and NDA filings.

In this position, the core responsibilities will include:

• Serve as a small molecule project team representative demonstrating knowledge of ADME, in vitro to in vivo correlation, in vitro to in vivo extrapolation, and PK/PD.
• Act as a subject matter expert in biotransformation, including but not limited to classical small molecules, antibody drug conjugates, and targeted protein degraders
• Design in vitro and in vivo experiments to evaluate the ADME/PK properties of small molecules, such as solubility, permeability, stability, plasma protein binding, blood-brain barrier penetration, metabolism, clearance, bioavailability, PK, and PD
• Apply software tools to analyze preclinical ADME/PK data and to predict PK parameters and/or pharmacological response of drug candidates across species
• Lead and contribute to the preparation of scientific reports and to submission of regulatory documents, such as IND and NDA filings
• Establish positive relationships and collaborations within PKDM and in cross-functional teams to optimize drug candidate profiles including a comprehensive understanding of potential drug-drug interactions and ensuring the selection of the appropriate dose and route of administration
• Contribute to PKDMs external eminence through authoring scientific publications and speaking publicly at scientific conferences

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of small molecule drug discovery and/or development in industry or similar experience

Or

Masters degree and 6 years of small molecule drug discovery and/or development in industry or similar experience

Or

Bachelors degree and 8 years of small molecule drug discovery and/or development in industry or similar experience

Preferred Qualifications:

• PhD in pharmacology, pharmacokinetic/pharmaceutical sciences, biochemistry, or a related field
• 5+ years of small molecule drug discovery and/or development in industry or similar experience
• Project team representative experience within the context of PKDM-related attributes
• Strong background and/or comprehensive training in small molecule biotransformation including knowledge of in vitro/ in vivo experimental design and analytical instrumentation that would be transferable to other modalities
• Excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment
• Knowledge of global regulatory guidance and extensive experience with writing scientific reports, PK written summaries, and/or response to regulatory questions to support IND and NDA filings
• Experience with leading teams of multiple scientists and delivering on objectives and key results

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.