Senior Director Of Translational Research

Description

Position Summary

The Senior Director of Translational Research will partner with a team of researchers focusing on translational experimentation and analytics for our discovery research, preclinical and clinical programs. The ideal candidate has strong strategic skills and will directly shape Anaptys' scientific and translational goals. Key aspects of this role will be to interface with external key opinion leaders in a collaborative manner and to support translational rationales and strategies in the clinic. This position will include oversight to direct and integrate bioinformatics approaches preclinically and clinically; the discovery, validation, and implementation of biomarkers to be used in clinical trials and building strong scientific and pharmacologic rationale for numerous programs by utilizing patient-derived samples. This position will work within the CMO organization (Translational Medicine physician, Clinical Development, Clinical Operations, Regulatory groups) with strong collaborations with Corporate Development and Research.

Essential Functions

• Lead translational collaborations with external KOLs to inform target validation, indication selection, and ongoing translational plans in the clinic.
• Lead and participate in translational strategic efforts to maximize the potential of checkpoint agonists and cellular therapies.
• Design and execute cross functional Translational Research studies supporting and bridging preclinical and clinical development of AnaptysBio's inflammation programs.
• Conduct analyses of biological pathways to establish relevance to disease indications of interest to AnaptysBio's therapeutic focus.
• Develop preclinical patient-related studies required for optimal characterization of pharmacology.Develop guidelines for selection, validation, and prioritization of Translational biomarkers, ensuring alignment with AnaptysBio's product development strategies.
• Work with Program Management to support program teams timelines and budgets
• Contribute to the preparation of documentation required for regulatory submissions, including INDs.

Requirements

Qualifications

Education & Experience: 

• M.D. and/or PhD with expertise in immunology. Experience in rheumatology and gastroenterology is of high interest.
• 12+ years of relevant, direct experience in preclinical/clinical development up to Phase 1 clinical studies.
• Proven experience in the translational medicine approach to the development of biologics

Knowledge and Competencies: 

• Technical credibility and expertise in Translational Biology; including hands-on experience working closely with research biology group to help progress molecules through preclinical development into the clinic.
• Capable of providing leadership in a cross functional team across Research and Clinical Development, without direct reports
• Strong management skills with 5+ years managing a team or group of scientists, and experience leading multi-disciplinary teams.
• Provides guidance to the scientific team responsible for the discovery and implementation of PD assays and biomarkers
• Provides guidance to the scientific assessment of MOA and indication selection 
• Provides guidance to the implementation of PD assays, biomarkers, and efficacy endpoints in clinical development
• Provides guidance to trial design and proof of mechanism
• Excellent leadership skills and proven ability to work within multi-disciplinary teams to influence the overall direction of projects. Strong communication skills and a positive collaborative mindset are desired.
• Prior experience of working across diverse therapeutic areas is highly desirable.

Physical Demands

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to sit and talk or hear. The employee frequently is required to use hands to finger, handle, or feel. The employee is occasionally required to stand, walk, and reach with hands and arms. The employee must occasionally lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision and ability to adjust focus in order to read.

Work Environment

The work environment characteristics are representative of those an employee encounters while performing the essential functions of this job, typically in an open office environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

The noise level in the work environment is usually moderate.

May be required to travel by plane or car.

This position requires working with biological and/or chemical hazards.

All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.