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. The job details are as follows:
What We Do
We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.
Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.
With over 100,000 patients on the organ transplant waitlist and only a fraction receiving the lifesaving organ they require, there is a great need for additional sources of transplantable organs. At Miromatrix, a leader in regenerative medicine and a subsidiary of United Therapeutics Corporation, we are working to address this unmet need by bioengineering human organs to help save and improve patients’ lives. Join our team as we continue to make history by developing life-saving therapies to help patients with liver and kidney disease.
How you’ll contribute
The Senior Scientist/Scientist Cell Sourcing will lead the development (Senior Scientist), implementation, and refinement of robust protocols for the isolation and expansion of primary liver and kidney cells. This individual must be an innovative and self-motivated scientist with demonstrated ability to develop and improve existing processes, creatively solve difficult problems, should be excellent at troubleshooting, and able to work well independently and in collaboration with a diverse team of multidisciplinary scientists and engineers diligently and carefully. This role, and team, will be tasked with developing large scale, GMP level protocols to supply cells for R&D cellularization efforts in decellularized liver and kidney scaffolds, and with providing necessary data and documentation support for the preparation of regulatory filings.
- Coordinate with R&D and manufacturing teams to generate technical plans to develop and optimize targeted primary cell isolation protocols from human liver and kidney tissue
- Draft protocols, experimental documentation strategies, summaries, and reports. Participate in drafting of documentation for regulatory submissions
- Work with a team on a flexible schedule, according to organ availability, to conduct primary cell isolation protocols
- Design and execute experiments to develop methods for downstream purification and expansion of primary liver and kidney cells
- Work with manufacturing and engineering teams to design methods of control for the generation of reliable primary cell manufacturing processes that will adhere to GMP standards
- Perform characterization of cells obtained from isolation and expansion protocols using standard techniques such as flow cytometry and IHC
- Assist in coordination and training activities for tech transfer of fully developed protocols to manufacturing teams
- Communicate using both oral presentations and written documents to broad level of audiences including R&D teams, quality, manufacturing, and upper management.
- Contribute to efforts to understand, explore, and incorporate new technologies to advance programs
- Serve as a technical and experience expert throughout the company in a given area and keep current in field
- Mentor, advise, and train junior staff
- Author and submit manuscripts, grants, and abstracts with approval of senior management
- Perform other duties as assigned
In addition the Senior Scientist will:
- Lead collaboration between manufacturing and engineering teams to design methods of control for the generation of reliable primary cell manufacturing processes that will adhere to GMP standards
- Lead efforts to identify, understand, explore, and incorporate new technologies to advance programs
- Lead tech transfer of fully developed protocols to manufacturing teams
For this role you will need
Senior Scientist:
Minimum Requirements
- Doctor of Philosophy (PhD) in Tissue Engineering, Biomedical Engineering, Biological Sciences, or related field
- 5+ years of relevant experience working with primary mammalian cell isolation and culture
- 1+ years of relevant industry experience working in a quality-controlled research environment
- Experience working with quality-controlled setting
- Experience working in a clinical setting and performing studies for regulatory submission preparation
- Ability to work in a fast-paced environment, including multi-tasking, flexibility, and
- adaptability
- Enthusiasm for a collaborative work culture and desire to make a positive impact
- Experience managing idea and/or experimental phase of complex R&D projects
- Excellent organizational, verbal, written, and interpersonal skills
- Experience with adherent mammalian cell culture
- Experience with primary cell isolations
- Background knowledge of liver and/or kidney function and experience working with cells from these organs
- Ability to work off hours when necessary according to organ availability
Preferred Qualifications
- Experience working with human tissue
- Background knowledge of perfusion control and fluid flow dynamics
- Experience with cell purification techniques such as MACS sorting or size exclusion
- Experience with flow cytometry
- Experience with immunohistochemistry or immunofluorescence staining
Scientist:
Minimum Requirements
- Doctor of Philosophy (PhD) in Tissue Engineering, Biomedical Engineering, Biological Sciences, or related field
- 2+ years of relevant experience working with primary mammalian cell isolation and culture
- 1+ years of relevant industry experience working in a quality-controlled research environment
- Ability to work in a fast-paced environment, including multi-tasking, flexibility, and
- adaptability
- Enthusiasm for a collaborative work culture and desire to make a positive impact
- Experience managing idea and/or experimental phase of complex R&D projects
- Excellent organizational, verbal, written, and interpersonal skills
- Experience with adherent mammalian cell culture
- Ability to work off hours when necessary according to organ availability
Preferred Qualifications
- Experience working with quality controlled setting (required Sr. Scientist)
- Experience working in a clinical setting and performing studies for regulatory submission preparation (required Sr. Scientist)
- Experience with primary cell isolations (required Sr. Scientist)
- Background knowledge of liver and/or kidney function and experience working with cells from these organs (required Sr. Scientist)
- Experience working with human tissue
- Background knowledge of perfusion control and fluid flow dynamics
- Experience with cell purification techniques such as MACS sorting or size exclusion
- Experience with flow cytometry
- Experience with immunohistochemistry or immunofluorescence staining
While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients.
United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities
