Scientist II, Computational Chemistry

We are seeking a highly talented and motivated computational chemist to join our team in San Diego. As part of a multi-disciplinary team comprising of leaders in the field of targeted protein degradation, you will be engaged in target selection and hit finding, through to lead optimization and drug candidate selection, as well as exploratory efforts to identify new aspects of this compelling field.

Job Responsibilities:

• Work as a member of the multidisciplinary team of structure biology, medicinal chemistry, and biology and support the team by providing computational expertise.
• Employ cutting-edge Computational Chemistry methods, including physics/ML based activity prediction, QSAR, pharmacophore modeling and ADMET modeling to enable prospective design and propose design strategies.
• Exploit structure/ligand virtual screening and generative AI methodologies to accelerate hit identification and hit-to-lead.
• Apply molecular dynamics to simulate protein flexibility to allow high-accuracy prediction of binding site, binding mode, and binding kinetics of small molecules.
• Investigate, explore, and implement state-of-the-art Computational Chemistry methods that potentially accelerate discovery of molecular glue.
• Develop custom tools to enable data analysis, sharing and visualization.

Required Qualifications:

• Ph.D. in Computational Chemistry, Chemoinformatics or related field; 2+ years of relevant industrial experience is preferred.
• Demonstrated strong track record of research accomplishment in Computational Chemistry, structure biology, and chemoinformatics.
• Deep understanding of protein-ligand interaction and principles of structure-based design.
• Expertise with traditional Computational Chemistry, which includes docking, pharmacophore modeling, homology modeling, and structure- and ligand-based virtual screening.
• Experience in physics-based activity prediction methods, including MM-GB/PBSA, FEP, and TI.
• Experience in application of MD packages (AMBER, GROMACS, OPENMM, and so on) to analyze protein-ligand or protein-protein interaction.
• Proficiency in scientific programming skills (e.g. Python, R) is essential.
• Familiarity with commercial Computational Chemistry suites. The Schrodinger and Openeye suites are preferred.
• Proficiency in Linux command-line and shell scripting.

Preferred Qualifications:

• Familiarity with AI/ML methodologies for activity/ADMET prediction is preferred.
• Expertise in protein-protein docking tools is plus.

What we offer:

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Company-paid external career development coaching program
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard)

Have Fun!

We believe in work/life balance and Fun is at the core of our Core Values. In addition to ongoing happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us:

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.

Neomorph is headquartered in San Diego, California, and has a key collaboration with the Center for Protein Degradation at the Dana-Farber Cancer Institute.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.