Company

Bristol-Myers Squibb CompanySee more

addressAddressSeattle, WA
type Form of workFull-Time
CategoryInformation Technology

Job description

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
Title: Scientist, Gene Delivery Process and Analytical Development
Location: Seattle, WA
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Cell Therapy is one of the most groundbreaking new forms of cancer treatment being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.
Position Summary
We are seeking an enthusiastic, self-driven individual to join the Gene Delivery Process Development team. Our team develops processes and technology underpinning critical raw materials used in the manufacturing of engineered T cells, including CRISPR-associated enzymes, guide RNA, and other forms of nucleic acids. The incoming Scientist will be responsible for providing technical subject matter expertise with internal and external development and manufacturing collaborators, following Quality by Design principles. The candidate will also contribute to wet lab experimental design and execution for gene editing raw materials to support current programs and advance our understanding in gene editing raw materials.
Key Responsibilities
  • Plan and execute experiments to support the implementation of process improvements to ribonucleoprotein (RNP) complexation unit operations and RNP performance in T cells
  • Serve as a technical subject matter expert (SME) for gene editing process development in analytical sub-team meetings, program-specific meetings, etc.
  • Work with internal collaborators to determine nucleic acid and RNP Quality Target Product Profiles (QTPP), perform CQA assessments, design process characterization studies, etc.
  • Manage projects with contract manufacturers to produce GMP-grade nucleic acids and enzymes
  • Author technical reports, patents, peer-reviewed publications, and regulatory documents
  • Train and manage junior scientists in lab, and with data review and presentation

Qualifications & Experience
  • Degree in Bioengineering, Biochemistry, Protein Engineering, or related discipline
  • 6+ years (B.S. or M.S.) or 0 - 2 years (Ph.D.) of experience
  • Familiarity with mammalian cell culture, preferably with primary cells.
  • Extensive knowledge and experience with CRISPR-Cas systems
  • Documented experience manufacturing gene editing raw materials for clinical or research applications
  • Effective communication skills, including written and oral communication to convey scientific concepts to research scientists, management teams, and external academic and industrial organizations
  • Proven ability to work effectively as a member of a multidisciplinary team
  • Strong organization, problem-solving, and project management skills with attention to detail
  • Experience and working knowledge of concepts related to the production of purified nucleic acids (including solid phase oligonucleotide synthesis) and recombinant proteins.
  • Experience working with contract manufacturing and development organizations, preferred
  • Experience developing GMP manufacturing processes for globally regulated products, such as vaccines, biologics, or cell & gene therapies, preferred
  • Experience with analytical techniques related to assessing the quality of nucleic acids and recombinant proteins including PAGE, analytical HPLC, ddPCR, Next-Generation Sequence (NGS), and dynamic light scattering (DLS) preferred
  • Previous work biochemically characterizing enzymes including enzyme kinetics, binding affinity determination, and structural elucidation, preferred

The starting compensation for this job is a range from $92,000 - $115,000, plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as "Transforming patients' lives through science™ ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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BMSCART
VETERAN
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as "Transforming patients' lives through science™ ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Refer code: 7320329. Bristol-Myers Squibb Company - The previous day - 2023-12-19 01:29

Bristol-Myers Squibb Company

Seattle, WA

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